Role of Anemia and Leukocytosis as Severity Predictors of Coronary Artery Disease Stenosis : A Retrospective Cross-sectional Study

M Saugi Abduh, Muhammad Rizki Triono, Retno Widyastuti

Abstract


Background: Anemia and leukocytosis were found to be associated with conditions that higher the risk for the formation of atherosclerotic plaque which will develop into cardiovascular disease. Basic laboratory parameters such as anemia and leukocytosis are not routinely used to assess Coronary Artery Disease (CAD) severity based on its stenosis. This study aimed to analyze the role of simple laboratory examiantion anemia and leukocytosis as predictors of the severity of stenosis in CAD. Methods: Cross-sectional approach was used in this study. Secondary data on CAD patients treated at Sultan Agung Islamic Hospital Semarang in 2022 were analyzed. Anemia and leukocytosis are the main risk factors analyzed in this study. Other risk factors such as gender, age, smoking status, hypertension and diabetes mellitus (DM) were also included in the analysis of this study. We performed bivariate analysis and multivariate analysis to see the relationship between these risk factors and the CAD stenosis severity. Results: Bivariate analysis with chi-square showed that anemia had a significant relationship with CAD severity (P<0.05). Multivariate analysis between anemia and smoking status reported that anemia was the most significant risk factor for the CAD stenosis severity (P<0.05). Conclusion: No association found between leukocytosis and CAD severity.


Keywords


anemia, severity, coronary artery disease, immunity, leukocytosis, stenosis

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References


Abduh, M. S., & Triono, M. R. (2022). Analisis Profil Lipid sebagai Prediktor Keparahan Stenosis Coronary Artery Disease yang Dinilai Menggunakan Gensini Score. Jurnal Wiyata: Penelitian Sains Dan Kesehatan, 9(2), 79–87. https://doi.org/10.56710/WIYATA.V9I2.603

Brown, J., Gerhardt, T., & Kwon, E. (2023). Risk Factors for Coronary Artery Disease. StatPearls Publishing LLC.

Cassar, A., Holmes, D. R., Rihal, C. S., & Gersh, B. J. (2009). Chronic Coronary Artery Disease: Diagnosis and Management. Mayo Clinic Proceedings, 84(12), 1130. https://doi.org/10.4065/MCP.2009.0391

Dai, X., Kong, T., & Zhang, X. (2022). Relationship between Increased Systemic Immune-Inflammation Index and Coronary Slow Flow Phenomenon. BMC Cardiovascular Disorders, 8(22), 362. https://doi.org/10.1186/s12872-022-02798-0

Dharma, S., Hapsari, R., & Siswanto, B. (2015). Blood Leukocyte Count on Admission Predicts Cardiovascular Events in Patients with Acute Non-ST Elevation Myocardial Infarction. Int J Angiol, 2, 127–132. https://doi.org/10.1055/s-0035-1544178

Ferrari, J. P., Lueneberg, M. E., Silva, R. L. da, Fattah, T., Gottschall, C. A. M., & Moreira, D. M. (2016). Correlation between Leukocyte Count and Infarct Size in ST Segment Elevation Myocardial Infarction. Archives of Medical Sciences. Atherosclerotic Diseases, 1(1), e44. https://doi.org/10.5114/AMSAD.2016.60759

Gan, T., Hu, J., Liu, W., Li, C., Xu, Q., Wang, Y., Lu, S., Aledan, A. K. O., Wang, Y., & Wang, Z. (2023). Causal Association Between Anemia and Cardiovascular Disease: A 2-Sample Bidirectional Mendelian Randomization Study. Journal of the American Heart Association, 12(12), 29689. https://doi.org/10.1161/JAHA.123.029689

Goel, H., Hirsch, J. R., Deswal, A., & Hassan, S. A. (2021). Anemia in Cardiovascular Disease: Marker of Disease Severity or Disease-modifying Therapeutic Target? Current Atherosclerosis Reports, 23(10). https://doi.org/10.1007/s11883-021-00960-1

Hajar, R. (2017). Risk Factors for Coronary Artery Disease: Historical Perspectives. Heart Views Journal, 3(18), 109–114. https://doi.org/10.4103/HEARTVIEWS.HEARTVIEWS_106_17.

Kose, N., Akin, F., & Ergun, G. (2019). The Association Between the Lymphocyte-to-Monocyte Ratio and Coronary Artery Disease Severity in Patients with Stable Coronary Artery Disease. Eur Rev Med Pharmacol Sci. https://doi.org/10.26355/eurrev_201903_17406

Lanser, L., Fuchs, D., & Shcarnagl, H. (2021). Anemia of Chronic Disease in Patients with Cardiovascular Disease. Front Cardiovascular Medicine. https://doi.org/10.3389/fcvm.2021.666638

Madjid, M., Awan, I., Willerson, J. T., & Casscells, S. W. (2004). Leukocyte Count and Coronary Heart Disease: Implications for Risk Assessment. Journal of the American College of Cardiology, 44(10), 1945–1956. https://doi.org/10.1016/J.JACC.2004.07.056

Metivier, F., Marchais, S. J., Guerin, A. P., Pannier, B., & London, G. M. (2000). Pathophysiology of Anaemia: Focus on the Heart and Blood Vessels. Nephrology, Dialysis, Transplantation: Official Publication of the European Dialysis and Transplant Association - European Renal Association, 15 Suppl 3(SUPPL. 3), 14–18.

https://doi.org/10.1093/OXFORDJOURNALS.NDT.A027970

Mirbolouk, F., Baharvand, F., Salari, A., Shakiba, M., Moayerifar, M., & Gholipour, M. (2020). Serum Parameters and Severity of Coronary Artery Disease in Patients with Acute Coronary Syndrome. Immunopathologia Persa, 6(1), 1–7. https://doi.org/10.15171/ipp.2020.12

Moriya, J. (2019). Critical Roles of Inflammation in Atherosclerosis. Journal of Cardiology. https://doi.org/10.1016/j.jjcc.2018.05.010

Mozos, I. (2015). Mechanisms Linking Red Blood Cell Disorders and Cardiovascular Diseases. BioMed Research International, 2015. https://doi.org/10.1155/2015/682054

Neglia, D., Rovai, D., Caselli, C., & Pietila, M. (2015). Detection of Significant Coronary Artery Disease by Noninvasive Anatomical and Functional Imaging. Circ Cardiovasc Imaging, 3. https://doi.org/10.1161/CIRCIMAGING.114.002179

Omidi, N., Sadeghian, S., Salarifar, M., Jalali, A., Abbasi, S. H., Yavari, N., Ghorashi, S. M., Alidoosti, M., & Poorhosseini, H. (2020). Relationship between the Severity of Coronary Artery Disease and Cardiovascular Risk Factors in Acute Coronary Syndrome: Based on Tehran Heart Center’s Data Registry. The Journal of Tehran University Heart Center, 15(4), 165. https://doi.org/10.18502/JTHC.V15I4.5942

Rana, J., Boekholdt, S., & Ridker, P. (2007). Differential Leucocyte Count and the Risk of Future Coronary Artery Disease in Healthy Men and Women. J Intern Med, 6. https://doi.org/10.1111/j.1365-2796.2007.01864

Rymer, & Jennifer, A. (2017). Anemia and Coronary Artery Disease: Pathophysiology, Prognosis, and Treatment. Coronary Artery Disease, 2(29), 161–167. https://doi.org/10.1097

Shahjehan, R. D. (2022). Coronary Artery Disease. StatPearls [Internet].

Stoner, L., Lucero, A. A., Palmer, B. R., Jones, L. M., Young, J. M., & Faulkner, J. (2013). Inflammatory Biomarkers for Predicting Cardiovascular Disease. Clinical Biochemistry, 46(15), 1353–1371. https://doi.org/10.1016/J.CLINBIOCHEM.2013.05.070

Turner, J., Parsi, M., & Badireddy, M. (2022). Anemia. StatPearls [Internet] Ncbi, 1.

Vooturi, S., Anil, P., & Monica, Y. (2023). Effects of Exercise Training and Physical Activity in Patients with Coronary Artery Disease. Https://Doi.Org/10.1177/26324636231158460, 4(2), 98–100. https://doi.org/10.1177/26324636231158460

Yan, X., Jin, J., & Zhang, M. (2020). Differential Leukocyte Counts and Cardiovascular Mortality in Very Old Patients with Acute Myocardial Infarction: a Chinese Cohort Study. BMC Cardiovasc Disord, 20. https://doi.org/10.1186/s12872-020-01743-3




DOI: http://dx.doi.org/10.30742/jikw.v13i1.3555

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