Hypertension: the risk factors of non-hemorrhagic stroke
DOI:
https://doi.org/10.30742/jikw.v15i1.4736Keywords:
Hypertension, risk factor, Non-Haemorrhage StrokeAbstract
Background: Stroke is the leading cause of disability and the third leading cause of death worldwide. This study aims to investigate hypertension as a risk factor for non-hemorrhagic stroke (NHS). Methods: This study was designed as a retrospective, observational, analytic case-control study involving a total of 112 participants. Data analysis utilised the chi-square test, with a significance level set at p < 0.05 and a 95% confidence interval (CI). Results: The findings revealed that NHS patients were predominantly in the 45-60 year age group (44.6%), primarily male (69.6%), and mostly of Balinese ethnicity (94.6%). A significant number of NHS patients were diagnosed with hypertension (53.6%). The most frequently reported clinical symptoms were weakness or paralysis in the extremities (94.6%). An improvement in outcomes was observed in 80.4% of patients, with a median length of hospital stay of 4 days. Laboratory data were normal, and CT scans identified hypodense lesions in 60.7% of cases. The results of the chi-square statistical analysis indicated an odds ratio (OR) of 2.65, with a 95% CI of 1.22–5.74 and p = 0.013. In conclusion, this study suggests that hypertension increases the risk of non-hemorrhagic stroke by 2.65 times compared to individuals without hypertension.
References
Abdu, H., Tadese, F., & Seyoum, G. (2021). Comparison of Ischemic and Hemorrhagic Stroke in the Medical Ward of Dessie Referral Hospital, Northeast Ethiopia: A Retrospective Study. Neurology Research International, 2021, 1–9. https://doi.org/10.1155/2021/9996958
Akimoto, T., Ogawa, K., Hara, M., Ninomiya, S., Ishihara, M., Morita, A., Kamei, S., & Nakajima, H. (2023). Clinical Features of Acute Ischemic Stroke Patients with Hypoesthesia as an Initial Symptom. Neurology International, 15(1), 508–517. https://doi.org/10.3390/neurolint15010030
Al-Harbi N, Alrasheedi MS, A. S. (2020). Hemoglobin level is associated with severe stroke among stroke patients in Saudi Arabia. Int J Health Sci (Qassim), 14(5), 18–22.
Al., L. F. et. (2025). Ischemic Stroke.
An, S. J., Kim, T. J., & Yoon, B.-W. (2017). Epidemiology, Risk Factors, and Clinical Features of Intracerebral Hemorrhage: An Update. Journal of Stroke, 19(1), 3–10. https://doi.org/10.5853/jos.2016.00864
Bai, X., Li, Z., Cai, Z., Yao, M., Chen, L., & Wang, Y. (2024). Gender differences in risk factors for ischemic stroke: a longitudinal cohort study in East China. BMC Neurology, 24(1), 171. https://doi.org/10.1186/s12883-024-03678-0
Chang, J. C. (2020). Stroke Classification: Critical Role of Unusually Large von Willebrand Factor Multimers and Tissue Factor on Clinical Phenotypes Based on Novel “Two-Path Unifying Theory†of Hemostasis. Clinical and Applied Thrombosis/Hemostasis, 26. https://doi.org/10.1177/1076029620913634
Chohan, S., Venkatesh, P., & How, C. (2019). Long-term complications of stroke and secondary prevention: an overview for primary care physicians. Singapore Medical Journal, 60(12), 616–620. https://doi.org/10.11622/smedj.2019158
Damilola Ashorobi, Muhammad Atif Ameer, R. F. (2024). Thrombosis.
Feigin, V. L., Krishnamurthi, R. V., Parmar, P., Norrving, B., Mensah, G. A., Bennett, D. A., Barker-Collo, S., Moran, A. E., Sacco, R. L., Truelsen, T., Davis, S., Pandian, J. D., Naghavi, M., Forouzanfar, M. H., Nguyen, G., Johnson, C. O., Vos, T., Meretoja, A., Murray, C. J. L., & Roth, G. A. (2015). Update on the Global Burden of Ischemic and Hemorrhagic Stroke in 1990-2013: The GBD 2013 Study. Neuroepidemiology, 45(3), 161–176. https://doi.org/10.1159/000441085
Fekadu, G., Chelkeba, L., & Kebede, A. (2019). Risk factors, clinical presentations and predictors of stroke among adult patients admitted to stroke unit of Jimma university medical center, south west Ethiopia: prospective observational study. BMC Neurology, 19(1), 187. https://doi.org/10.1186/s12883-019-1409-0
Ferrari, F., Moretti, A., & Villa, R. (2022). Hyperglycemia in acute ischemic stroke: physiopathological and therapeutic complexity. Neural Regeneration Research, 17(2), 292. https://doi.org/10.4103/1673-5374.317959
Gu, Y., Zhou, C., Piao, Z., Yuan, H., Jiang, H., Wei, H., Zhou, Y., Nan, G., & Ji, X. (2022). Cerebral edema after ischemic stroke: Pathophysiology and underlying mechanisms. Frontiers in Neuroscience, 16. https://doi.org/10.3389/fnins.2022.988283
Hägg-Holmberg, S., Dahlström, E. H., Forsblom, C. M., Harjutsalo, V., Liebkind, R., Putaala, J., Tatlisumak, T., Groop, P.-H., & Thorn, L. M. (2019). The role of blood pressure in risk of ischemic and hemorrhagic stroke in type 1 diabetes. Cardiovascular Diabetology, 18(1), 88. https://doi.org/10.1186/s12933-019-0891-4
Kuriakose, D., & Xiao, Z. (2020). Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives. International Journal of Molecular Sciences, 21(20), 7609. https://doi.org/10.3390/ijms21207609
Kushner, A., West, W.P., Suheb, M.K., & Pillarisetty, L. S. (2022). Vircow Triad.
Kusuma, N. D., Ardhi, M. S., Widodo, W., & Setyowatie, S. (2024). Profile Patients based on Risk Factors for Ischemic Stroke in the Neurology Inpatient Ward of Dr. Soetomo General Academic Hospital Surabaya during the Period of January to June 2022. AKSONA, 4(2), 65–73. https://doi.org/10.20473/aksona.v4i2.52354
Lin, M. P., & Liebeskind, D. S. (2016). Imaging of Ischemic Stroke. Continuum, 22(5), 1399–1423. https://doi.org/10.1212/CON.0000000000000376
Nair, S., Sylaja, P., Sreedharan, S., & Sarma, S. (2017). Maintenance of normoglycemia may improve outcome in acute ischemic stroke. Annals of Indian Academy of Neurology, 20(2), 122. https://doi.org/10.4103/0972-2327.194301
nnita Annita, Deswita Deswita, A. K. (2020). PERBEDAAN KADAR HEMOGLOBIN, NILAI HEMATOKRIT DAN JUMLAH ERITROSIT PADA STROKE ISKEMIK DAN STROKE HEMORAGIK DIFFERENCES OF HEMOGLOBIN LEVEL, HEMATOCRITE VALUE AND THE NUMBER OF ERYTHROCYTE IN ISCHEMIC AND HEMORRHAGIC STROKE. Medika Saintika, 11(2), 247–251.
Perdana, P. C., Ardhi, M. S., & Susanto, H. (2024). PROFILE OF CHARACTERISTIC, RISK FACTOR, AND CLINICAL SEVERITY OF ISCHEMIC STROKE PATIENTS. MNJ (Malang Neurology Journal), 10(1), 35–39. https://doi.org/10.21776/ub.mnj.2024.010.01.8
Rajati, F., Rajati, M., Rasulehvandi, R., & Kazeminia, M. (2023). Prevalence of stroke in the elderly: A systematic review and meta-analysis. Interdisciplinary Neurosurgery, 32, 101746. https://doi.org/10.1016/j.inat.2023.101746
Restikasari, N. T., Gamayani, U., Amalia, L., Dian, S., & Cahyani, A. (2022). Characteristics and Risk Factors of Patients with Acute Ischemic Stroke in Dr. Hasan Sadikin General Hospital Bandung, Indonesia. Althea Medical Journal, 9(4). https://doi.org/10.15850/amj.v9n4.2362
Saefurrohim, M. Z., Azam, M., Rahayu, S. R., & Cahyati, W. H. (2022). Incidence of Stroke and Associated Risk Factors in Bogor, Indonesia: A Nested Case-Control Study. Kemas, 17(4), 621–629. https://doi.org/10.15294/kemas.v17i4.36022
Sanyasi, R. D. L. R., & Pinzon, R. T. (2018). Clinical Symptoms and Risk Factors Comparison of Ischemic and Hemorrhagic Stroke. Jurnal Kedokteran Dan Kesehatan Indonesia, 9(1), 5–15. https://doi.org/10.20885/JKKI.Vol9.Iss1.art3
Sarfo, F. S., Ovbiagele, B., Akpa, O., Akpalu, A., Wahab, K., Obiako, R., Komolafe, M., Owolabi, L., Ogbole, G., Calys-Tagoe, B., Fakunle, A., Sanni, T., Mulugeta, G., Abdul, S., Akintunde, A. A., Olowookere, S., Uvere, E. O., Ibinaiye, P., Akinyemi, J., … Owolabi, M. (2022). Risk Factor Characterization of Ischemic Stroke Subtypes Among West Africans. Stroke, 53(1), 134–144. https://doi.org/10.1161/STROKEAHA.120.032072
Smith, L., Chakraborty, D., Bhattacharya, P., Sarmah, D., Koch, S., & Dave, K. R. (2018). Exposure to hypoglycemia and risk of stroke. Annals of the New York Academy of Sciences, 1431(1), 25–34. https://doi.org/10.1111/nyas.13872
Turana, Y., Tengkawan, J., Chia, Y. C., Nathaniel, M., Wang, J., Sukonthasarn, A., Chen, C., Minh, H. Van, Buranakitjaroen, P., Shin, J., Siddique, S., Nailes, J. M., Park, S., Teo, B. W., Sison, J., Ann Soenarta, A., Hoshide, S., Tay, J. C., Prasad Sogunuru, G., … Kario, K. (2021). Hypertension and stroke in Asia: A comprehensive review from HOPE Asia. The Journal of Clinical Hypertension, 23(3), 513–521. https://doi.org/10.1111/jch.14099
Venketasubramanian, N., Yoon, B. W., Pandian, J., & Navarro, J. C. (2017). Stroke Epidemiology in South, East, and South-East Asia: A Review. Journal of Stroke, 19(3), 286–294. https://doi.org/10.5853/jos.2017.00234
Vidista. (2017). Correlation Between Grade of Hypertension and Length of Stay of Stroke Patients in Sleman General Hospital’. The 2nd International Conference on Cardiovascular Diseases, Pp.
Vincent, M., Sereke, S. G., Nassanga, R., Robert, M., & Ameda, F. (2023). Correlation between clinical and brain computed tomography findings of stroke patients: A crossâ€sectional study. Health Science Reports, 6(5). https://doi.org/10.1002/hsr2.1248
Wang, C., Du, Z., Ye, N., Shi, C., Liu, S., Geng, D., & Sun, Y. (2022). Hyperlipidemia and hypertension have synergistic interaction on ischemic stroke: insights from a general population survey in China. BMC Cardiovascular Disorders, 22(1), 47. https://doi.org/10.1186/s12872-022-02491-2
Yousufuddin, M., & Young, N. (2019). Aging and ischemic stroke. Aging, 11(9), 2542–2544. https://doi.org/10.18632/aging.101931
Zhang, R., Xu, Q., Wang, A., Jiang, Y., Meng, X., Zhou, M., Wang, Y., & Liu, G. (2021). Hemoglobin Concentration and Clinical Outcomes After Acute Ischemic Stroke or Transient Ischemic Attack. Journal of the American Heart Association, 10(23). https://doi.org/10.1161/JAHA.121.022547
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