Incision Wound Healing Activity of Red Betel Leaf (Piper crocatum) in Wistar Rats

Maharani Rizki Amanda Barokah; Lusiani Tjandra; Andra Agnes Al Aska; Atik Sri Wulandari

doi:10.30742/jikw.v15i1.5054

Authors

Maharani Rizki Amanda Barokah Faculty of Medicine, Universitas Wijaya Kusuma Surabaya, Indonesia
Lusiani Tjandra Faculty of Medicine, Wijaya Kusuma Surabaya University
Andra Agnes Al Aska Department of Biomedical and Biomolecular Research, Faculty of Medicine, Universitas Wijaya Kusuma Surabaya
Atik Sri Wulandari Department of Public Health, Faculty of Medicine, Universitas Wijaya Kusuma Surabaya

DOI:

https://doi.org/10.30742/jikw.v15i1.5054

Abstract

Background: Incisional wounds are tissue injuries that require
appropriate management to prevent complications. Red betel
leaf (Piper crocatum) contains bioactive compounds with antiinflammatory, antioxidant, and antimicrobial properties that
may enhance wound healing. Objective: This study aimed to
evaluate the wound-healing activity of red betel leaf extract in
Wistar rats with incisional wounds. Methods: The research used
an experimental laboratory design in which test animals were
divided into five groups.: three treatment groups with extract
concentrations of 5%, 10%, and 15%, a positive control group
using 10% povidone iodine, and a negative control group using
0.9% NaCl. Observed parameters included redness, edema,
exudate, granulation tissue formation, and wound length
changes during the healing process. Result: The results
demonstrated that Piper crocatum extract, particularly at a
concentration of 15%, significantly reduced inflammatory signs
(erythema, edema, and exudate) and accelerated granulation
tissue formation and wound contraction compared with the
control groups (p < 0.05). Conclusion: These findings suggest
that red betel leaf extract possesses pharmacological activity
that accelerates wound healing and has potential as a
complementary therapy in wound management.