Prolonged Central Venous Catheterization and Suspected Bloodstream Infection in Neonates: A NICU Study

Artisyanti Dwi Nissa Nissa; Sapta Prihartono; Densy Violina; Verna Biutifasar; Vendra Setiawan; Pramta Anindya Nugraheni

doi:10.30742/jikw.v15i2.5211

Authors

Artisyanti Dwi Nissa Medical Education Study Program, Faculty of Medicine, Universitas Hang Tuah
Sapta Prihartono Pediatric Surgery Sub Department, Surgery Department, Faculty of Medicine, Universitas Hang Tuah
Densy Violina Dermatology and Venereology Department, Faculty of Medicine, Universitas Hang Tuah
Verna Biutifasar Clinical Pathology Department, Faculty of Medicine, Universitas Hang Tuah
Vendra Setiawan Department of Pharmaceutical Manufacturing, Faculty of Pharmacy, University of Surabaya, 60293, East Java, Indonesia https://orcid.org/0009-0000-6842-297X
Pramta Anindya Nugraheni Department of Child Health, Faculty of Medicine, Universitas Hang Tuah, Surabaya, 60244, East Java, Indonesia

DOI:

https://doi.org/10.30742/jikw.v15i2.5211

Abstract

Background: Central venous catheterization is an important step for newborns in the NICU. Still, keeping the line in for too long can raise the chance of infection. One concern is a suspected bloodstream infection. These infections can make outcomes much worse for babies, including higher risk of death and serious illness. Objective: This study aimed to examine the association between prolonged central venous catheterization and suspected bloodstream infection in neonate patients. Methods: This retrospective cohort study included neonates admitted to the NICU of RSPAL dr. Ramelan Surabaya who underwent CVC placement from 2023-2025. Demographic, clinical, and laboratory data, including CVC duration and suspected CLABSI, were collected from medical records. The association between CVC duration and suspected CLABSI was analyzed using the Spearman and Fisher’s exact test, with p < 0.05 considered statistically significant. Result: Data were obtained from 52 neonates with an average age of 4.885 ± 6.767 days and an average CVC placement duration/ICU stay of 15.15 ± 10.68 days; 3.7% of the neonates with a CVC had suspected bloodstream infection, and no significant difference was identified (p = 1) in the analysis performed using Fisher's exact test. Conclusion: There is no significant difference between prolonged central venous catheterization and suspected blood stream infection

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