Potency of Ethanol Extract Celery (Apium graveolens L.) Stalk as Anti-Cholesterol
Abstract
Increasing levels of blood cholesterol is one of the risk factors for atherosclerosis. Currently, experts have been trying used herbal medicine as an alternative treatment of atherosclerosis. One of the highlights is the use of celery stalks. Celery is generally used as a flavouring dish. In addition, celery stalks are believed able to reduce cholesterol levels because they contain flavonoids, tannins, and saponins. This study was aim to determine the effect of celery stalk ethanol extract to reduce LDL an increase of HDL level in rats after fed high-fat diet. Randomized Post Test Only Control Group Design was used to measure the HDL and LDL blood serum levels of male Wistar (Rattus norvegicus) rats fed a high-fat diet. This study was used 27 male Wistar rats (Rattus norvegicus) divided into 3 groups; K1 was only given regular feed and water, K2 was given a high-fat diet and water, K3 was given a high-fat diet and celery stalk extract at a dose of 75mg/kg BW/day for 14 days. The data were analysed by ANOVA test and Tukey HSD test. The results of the ANOVA test showed a significance value of p-value of LDL = 0.000 and HDL p-value = 0.536. Celery stalk extract (Apium graviolens L) had an effect on decreasing LDL levels but not on increasing HDL blood serum levels of white Wistar rats (Rattus norvegicus) given high-fat diet.
Keywords
Full Text:
PDFReferences
Dwisatyadini, M. (2010). Pemanfaatan tanaman obat untuk pencegah an dan pengo batan penyakit degeneratif. 237–270.
Departemen Kesehatan Republik Indonesia. (2017). Survei Kesehatan Rumah Tangga (SKRT). Jakarta: DEPKES RI.
Dalimarta, S. (2016). Atlas Tumbuhan Obat Indonesia (Vol.2). Jakarta: PT. Trubus Agriwidya.
Guyton, A.C., & Hall, J. E. (2016). Buku Ajar Fisiologi Kedokteran (12th ed). Jakarta : EGC, 1022.
Meirindasari, N., Murwani, H., Tjahjono, K. (2013). Pengaruh Pemberian Jus Biji pepaya (Carica papaya Linn.) terhadap Kadar Kolesterol Total tikus Sprague Dwaly Dislipidemia. Journal of Nitrition College. 2(3), 330–338.
Muchatadi D. (2013). Antioksidan & Kiat Sehat di Usia Produktif. Alfabeta, 81.
Murray, RK, Granner, DK, & Rodwell, VW., (2017). Biokimia harper (30th ed), Buku Kedokteran EGC, Jakarta
Naim, F., Marianti, A., Susanti, R. (2017). Aktivitas Ekstrak Daun Jati Belanda terhadap Kadar Kolesterol HDL dan LDL pada Tikus Hiperkolesterolemnia. Life Science. 6(1), 1–8.
Salman, H.R. Batool Al-Khafaji, N. J. M. (2013). Effect of Apium graveolens Leaves and Stalks in Reducing the Side Effects of Doxorubicin in Male Rabbits. Medical Journal of Babylon, 10(1), 46–74.
Shi, Y., Xie, J., Chen, R., Liu, G., Tao, Y., Fan, Y., Wang, X., Li, L., & Xu, J. (n.d.). Inhibitory effects of astilbin, neoastilbin and isoastilbin on human cytochrome CYP3A4 and 2D6 activities. 0–2. https://doi.org/10.1002/bmc.5039
Sherwood, LZ., (2017). Fisiologi Manusia dari Sel ke Sistem. (8th ed). Jakarta: EGC, 595-677.
Suparjo. (2018). Saponin peran dan pengaruhnya bagi ternak dan manusia. Fakultas Peternakan. Universitas Jambi. Jambi.
Susanti, R., & Yuniastuti, A. (2012). Unnes Journal of Life Science Efektivitas Ekstrak Tanin Seledri Terhadap Profil Lipid Tikus Putih Hiperkolesterolemi Abstrak Abstra ct. 1(2).
WHO (2020). HEARTS technical package for cardiovascular disease management in primary health care: risk based CVD management.
Wulandari, D. I., Fitrianingsih, S. P., & Mulqie, L. (1989). Uji Aktivitas Antiinflamasi Ekstrak Etanol Herba Seledri ( Apium graveolens L.) terhadap Tikus Wistar Jantan. 59–66.
DOI: http://dx.doi.org/10.30742/jikw.v11i2.2014
Refbacks
- There are currently no refbacks.
Copyright (c) 2022 I Made Subhawa Harsa, Andiani Andiani, Harsono Wiradinata, Putu Oky Ari Tania
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Jurnal Ilmiah Kedokteran Wijaya Kusuma is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
