Pemanfaatan Seduhan Daun Ashitaba dengan Simvastatin dalam Menurunkan Kadar LDL Tikus Putih Jantan Strain Wistar

Ernawati Ernawati, Theresia Ratnasari Widjaja


High levels of blood cholesterol or hypercholesterolemia is an important risk factor for a cardiovascular disease. In order to overcome this problem, giving statins drug such as simvastatin is an intervention that is often applied. Besides using this drug, it can also be accompanied by consuming herbal plants which is Ashitaba leaves (Angelica keiskei). It contains Chalcones which demonstrates anti tumour property and also antioxidant activity that can lower cholesterol levels, especially LDL in the blood.

This study aimed to investigate the effect of Ashitaba leaves (Angelica keiskei) steeping administration in assisting simvastatin drugs to decrease the levels of Low Density Lipoprotein (LDL) in the blood serum of male white rats Strain wistar (Rattus Norvegicus) with hypercholesterolemia. The population for this study was male white rats Strain wistar (Rattus Norvegicus) with samples taken in this study were 33 white rats. Data analysis for this study is using One Way Anova test.

The result showed that supplementation of simvastatin treatment using steeping Ashitaba leaves might slightly reduce LDL level among male white rats Strain wistar (Rattus Norvegicus) with hypercholesterolemia. However, the result demonstrated not significant different. 

To assist simvastatin drugs in lowering LDL levels in male white rats Strain wistar (Rattus Norvegicus) which is made to be hypercholesterolemia can lower LDL levels slightly but not significantly (p-value = 0,177) which is >a (0,05).


Ashitaba leaves; Simvastatin; LDL levels;Male white rats; Hypercholesterolemia

Full Text:



Bantas, Krisnawaty. Agustina, Farida Mutiarawaty Tri. Zakiyah, Dnie. 2012. Hypercholesterolemia Risk on Workers in Industrial Estate.

Adesta, Fajar E. Rahmawati, Dani. Surastri, Budhi. 2010. Pegaruh Pemberian Simvastation Terhadap Fungsi Memori Jangka Pendek Tikus Wistar Hiperlipidemi.

Nagata J, Morino T, Saito M. 2007. “Effects of dietary Angelica keiskei onserum and liver lipid profi les, and body fat accumulations in rats”.Journal of Nutrition Scientific Vitaminology, National Institute of Health and Nutrition, Tokyo.

Sudarmika I Wayan dan Jawi I Made.2012. Ekstrak Air Daun Ubijalar Ungu Memperbaiki Profil Lipid Dan Meningkatkan Kadar SOD Darah Tikus Yang Diberi Makanan Tinggi Kolesterol. Jurnal Ilmiah Kedokteran, Medicina volume 43 nomor 2. Bali.

Arief, M. et al. 2012.Potensi Bunga Karamunting (Melastoma Malabathricum L.) Terhadap Kadar Kolesterol Total Dan Trigliserida Pada Tikus Putih Jantan Hiperlipidemia Yang Diinduksi Propiltiourasil.Prestasi, Volume 1, Nomor 2. Banjarmasin.

Stancu, Camelia. Sima, Anca. 2001. Statins : mechanism of action and effects. J.Cell.Mol.Med. Vol 5, No 4, 2001 pp. 378-387.



  • There are currently no refbacks.

Copyright (c) 2018 Ernawati Ernawati, Theresia Ratnasari Widjaja

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.



Jurnal Ilmiah Kedokteran Wijaya Kusuma 

ISSN: 1978-2071(print); 2580-5967 (online)
Published by the Institute for Research and Community Services (LPPM) of University of Wijaya Kusuma Surabaya.
Surabaya, Indonesia
Creative Commons License
All publications by Jurnal Ilmiah Kedokteran Wijaya Kusuma are licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
counter View My Stats