Effect of Rhizophora apiculata bark extract on SGOT levels in Rattus norvegicus induced by dexamethasone
Abstract
Background: The liver's presence of fat has a histological picture with lipids>5%, and no secondary cause is called NAFLD. Rhizophora apiculata can serve as a therapeutic or prophylactic agent in NAFLD due to its flavonoid content. Objective: to ascertain the impact of Rhizophora apiculata extract administration on SGOT levels in white rats subjected to dexamethasone induction. Methods: The experimental animals were categorized into four groups: K- group, no treatment; K+ group, which was administered dexamethasone at a dosage of 5 mg/kg BW from the 15th to the 21st day; KP1 group, which received Rhizophora apiculata ethanol extract at a dosage of 56 mg/kg BW from the 8th to the 21st day, along with dexamethasone at 5 mg/kg BW from the 15th to the 21st day; and KP2 group, which was given Rhizophora apiculata ethanol extract at 56 mg/kg BW and dexamethasone at 5 mg/kg BW from the 15th to the 21st day. Result: The data were not normally distributed (p < 0.05), so the Kruskal-Wallis test was carried out, which yielded p < 0.05. Consequently, the post hoc test was continued, namely the Mann-Whitney U test. The post hoc test of the K-group and K+ obtained p < 0.05. The K+ group and KP1 and KP2 showed P > 0.05, indicating no significant difference. Conclusion: The Rhizophora apiculata extract at a dose of 56 mg/kg BW for 7 days can reduce SGOT levels in the Kp2 group.
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Alsareii, S. A., Manaa Alamri, A., AlAsmari, M. Y., Bawahab, M. A., Mahnashi, M. H., Shaikh, I. A., Shettar, A. K., Hoskeri, J. H., & Kumbar, V. (2022). Synthesis and Characterization of Silver Nanoparticles from Rhizophora apiculata and Studies on Their Wound Healing, Antioxidant, Anti-Inflammatory, and Cytotoxic Activity. Molecules, 27(19). https://doi.org/10.3390/molecules27196306
Banjarnahor, S. D. S., & Artanti, N. (2014). Antioxidant properties of flavonoids. In Medical Journal of Indonesia (Vol. 23, Issue 4, pp. 239-244). Faculty of Medicine, Universitas Indonesia. https://doi.org/10.13181/mji.v23i4.1015
Batista, E. K., Lima, L. M. A. de, Gomes, D. A., Crans, D. C., Silva, W. E., Belian, M. F., & Lira, E. C. (2024). Dexamethasone-Induced Insulin Resistance Attenuation by Oral Sulfur-Oxidovanadium(IV) Complex Treatment in Mice. Pharmaceuticals, 17(6). https://doi.org/10.3390/ph17060760
BeyoÄŸlu, D., Popov, Y. V., & Idle, J. R. (2024). Metabolomic Hallmarks of Obesity and Metabolic Dysfunction-Associated Steatotic Liver Disease. In International Journal of Molecular Sciences (Vol. 25, Issue 23). Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/ijms252312809
Di Pasqua, L. G., Cagna, M., Berardo, C., Vairetti, M., & Ferrigno, A. (2022). Detailed Molecular Mechanisms Involved in Drug-Induced Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis: An Update. Biomedicines, 10(1). https://doi.org/10.3390/biomedicines10010194
El-Helbawy, N. F., Abd Al-Salam, A. A. A.-H., El-Sawaf, M. E.-S., & El-Deeb, S. A. E.-A. (2020). Hyperbaric Oxygen Therapy Ameliorates the Harmful Effects of Dexamethasone-Induced Diabetes on Liver and Pancreas of Adult Male Albino Rats. Journal of Advances in Medicine and Medical Research, 32(5), 40–54. https://doi.org/10.9734/jammr/2020/v32i530415
Guney-Coskun, M., & Basaranoglu, M. (2024). Interplay of gut microbiota, glucagon-like peptide receptor agonists, and nutrition: New frontiers in metabolic dysfunction-associated steatotic liver disease therapy. World Journal of Gastroenterology, 30(43), 4682-4688. https://doi.org/10.3748/wjg.v30.i43.4682
Handajani, F. (2019). Oksidan adan antioksidan dan antioksidan pada beberapa penyakit dan proses penuaan (Vol. 15, Issue 2).
Handajani, F. (2021). Metode Pemilihan dan pemnbuatan hewan model beberapa penyakit pada penelitian eksperimental.
Handajani, F., Permana, I. G. P. B. T., Taruna, D., & Untari, N. K. S. D. (2023). Efek Pemberian Eucheuma spinosum sebagai Profilaksis dalam Penghambatan Peningkatan SGPT pada Tikus yang Diinduksi Dexamethasone. Hang Tuah Medical Journal, 21(1), 10-24. https://doi.org/10.30649/htmj.v21i1.359
Hasona, N. A., Alrashidi, A. A., Aldugieman, T. Z., Alshdokhi, A. M., & Ahmed, M. Q. (2017). Vitis vinifera extract ameliorate hepatic and renal dysfunction induced by dexamethasone in albino rats. Toxics, 5(2), 1-9. https://doi.org/10.3390/toxics5020011
Jairaman, C., Matou-Nasri, S., Alehaideb, Z. I., Yacoob, S. A. M., Venkataraman, A., Sivanesan, S. K., Vijayaraghavan, R., Nagarajan, Y., Gnanadesigan, M., Packiasamy, R., Pari, S. M., & Ramesh, S. (2021). Rhizophora Mucronata Lam. (Mangrove) Bark Extract Prevents
Ethanol-induced Liver Injury, Oxidative Stress and Apoptosis in Swiss Albino Mice. https://doi.org/10.21203/rs.3.rs-1132624/v1
Latompai, N. I., Achmad, M. A., Dhafir, F., & Made Budiarsa, I. (2020). Analisis Kandungan Protein Buah Mangrove (Rhizophora mucronata L.) dan Pemanfaatannya sebagai Media Pembelajaran Analysis of the Protein Content of Mangrove Fruit (Rhizophora mucronata L.) and Its Utilization as a Learning Media (Vol. 8, Issue 2). http://jurnal.fkip.untad.ac.id
Li, S., Tan, H., Wang, N., Zhang, Z., Lao, L., Wong, C., & Feng, Y. (2015). The Role of Oxidative Stress and Antioxidants in Liver Diseases. October, 26087-26124. https://doi.org/10.3390/ijms161125942
Maisarah, M., Chatri, M., & Advinda, L. (n.d.). Characteristics and Functions of Alkaloid Compounds as Antifungals in Plants Karakteristik dan Fungsi Senyawa Alkaloid sebagai Antifungi pada Tumbuhan.
Majeed, M., Pandey, A., Bani, S., Bhat, B., & Muthuraman, G. (2019). Hepatoprotective Effect of Garcinol in Acute Paracetamol Induced and Chronic Alcohol Induced Liver Injury in Experimental Rats. International Journal of Research Studies in Medical and Health Sciences, 4(7), 11-20.
Massart, J., Begriche, K., Corlu, A., & Fromenty, B. (2022). Xenobiotic-Induced Aggravation of Metabolic-Associated Fatty Liver Disease. In International Journal of Molecular Sciences (Vol. 23, Issue 3). MDPI. https://doi.org/10.3390/ijms23031062
Mustofa, S., Hutami, I. P., & Sarwindah, D. (2024). Acute toxicity test of Rhizophora apiculata bark extract on rat liver and kidney histology using fixed dose method. Acta Biochimica Indonesiana, 6(2), 144. https://doi.org/10.32889/actabioina.144
Rahayuningsih, S. R., Anindyta, A., & Mayanti, T. (2021). Sitotoksisitas Ekstrak Etanol dan n-Heksana Daun Rhizopora Apiculata dengan Indikator Indeks Mitosis Allium Cepa. Journal of Marine Research, 10(4), 545-550. https://doi.org/10.14710/jmr.v10i4.31777
Rahayuningsih, S. R., Mayanti, T., & Azzahra, F. (2023). Efek Sitotoksisitas Dan Genotoksisitas Dari Fraksi-Fraksi Ekstrak Etanol Daun Rhizopora stylosa Griff. Terhadap Pembelahan Sel Dan Kromosom Pada Akar Allium cepa L. Journal of Marine Research, 12(4), 701-716. https://doi.org/10.14710/jmr.v12i4.41360
Rajendran, P., Nandakumar, N., Rengarajan, T., Palaniswami, R., Gnanadhas, E. N., Lakshminarasaiah, U., Gopas, J., & Nishigaki, I. (2014). Antioxidants and human diseases. Clinica Chimica Acta, 436, 332-347. https://doi.org/10.1016/j.cca.2014.06.004
Razzaq, S. A., Jawad Jaber, I., Kadhim, S. A., & Abbas, A. A. (n.d.). Pharmacological Effects of Dexamethasone in Rats. In Indian Journal of Forensic Medicine & Toxicology (Vol. 14, Issue 3).
Sawy, A., ElMaddawy, Z., & Ashoura, N. (2018). Role of Silymarin in
Restoring the Deleterious Effects induced by Dexamethasone in Male
Rats. Alexandria Journal of Veterinary Sciences, 59(2), 125. https://doi.org/10.5455/ajvs.5950
Sulaiman, A. S. (2023). Perlemakan Hati Non-Alkoholik dan Risiko Fibrosis Hati pada Pasien Hepatitis B Kronik. Jurnal Penyakit Dalam Indonesia, 10(3). https://doi.org/10.7454/jpdi.v10i3.1456
Suleman, M. (2018). Antioxidants, its role in preventing free radicals and infectious diseases in human body. Pure and Applied Biology, 7(4), 380-388. https://doi.org/10.19045/bspab.2018.700197
Topal, E., Aydemir, K., Çağlar, Ö., Arda, B., Kayabaşı, O., Yıldız, M., Özyılmaz, E., & Erbaş, O. (2021). E N TA L AND B A S IC Fatty Liver Disease: Diagnosis and Treatment. Journal of Experimental and Basic Medical Sciences, 2(3), 343–357. https://doi.org/10.5606/jebms.2021.75676
Vittaya, L., Charoendat, U., Janyong, S., Ui-eng, J., & Leesakul, N. (2022). Comparative analyses of saponin, phenolic, and flavonoid contents in various parts of Rhizophora mucronata and Rhizophora apiculata and their growth inhibition of aquatic pathogenic bacteria. Journal of Applied Pharmaceutical Science, 12(11), 111-121. https://doi.org/10.7324/JAPS.2022.121113
DOI: http://dx.doi.org/10.30742/jikw.v14i2.4640
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