The influence of leaf infusion administration of Angelica keiskei with Simvastatin on lowering triglyceride levels in Rattus norvegicus

Cecilia Febriani Marentek, Ernawati Ernawati

Abstract


Ashitaba is one from many plant that contained flavonoid. Flavonoid is antioxidant that belong to phenols. If we compare between ahitaba and vitamin C, ashitaba have hundred times more effective than vitamin c and twenty-five more effective then vitamin E. Antioxidant may reduce cholesterol by inhibiting oxidation reaction so that cholesterol can be easily pass through the arteries and its plug. This research aims to know what is the influence of ashitaba (Angelica keiskei) assisting simvastatin  in lowering triglyceride levels in strain wistar white male rats (Rattus norvegicus) that in hypertriglycerid. The population on this research is strain wistar white rats (Rattus norvegicus), male, 100 g, 2 months age with health physical and total sample are 33 rats. The result from this research proved that there is no influence of ashitaba (Angelica keiskei) assisting simvastatin in lowering triglicyride levels in strain wistar white male rats (Rattus norvegicus) that in hypertriglycerid. It can caused by competituve reaction between ashitaba and simvastatin that they were blocking each other.


Keywords


Ashitaba leaves (Angelica keiskei); Simvastatin Drug; Triglyceride Rate; Hypertriglyceride; Rattus norvegicus

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References


Jafar Nurhaedar, Dr.Dra.Apt,M.Kes. 2011. Sindrom Metabolik. Fakultas Kesehatan Masyarakat Universitas Hasanuddin. Makassar, Hal:25-26

Melatunan Melda, Tiho Murniati, dan Mewo Yanti. 2014. Hubungan Kadar Triasilgliserol Darah Dengan Kadar High Sensitivity C-Reactive Protein Pada Remaja Obes. Department of Biochemistry Faculty of Meidicine Universitas Sam Ratulang. Manado, Hal:2

Susanti Erna dan Ratnawati. 2011. Efek Ateroprotektif dan Vasoprotektif Katekin The Hijau Terhadap Ekspresi eNOS Pada Tikus Wistar Jantan Dengan Diet Tinggi Lemak. Malang, Hal:2-3

Fatmawati Erni. 2008. Pengaruh Lama Pemberian Ekstrak Daun Sambiloto (Andrographis Paniculata Ness.) TerhadapKadar Kolesterol, Ldl (Low Density Lipoprotein), HDL (High Density Lipoprotein) Dan Trigliserida Darah Tikus(Rattus Norvegicus) Diabetes. Fakultas Sains Dan Teknologi Universitas Islam Negeri (UIN). Malang, Hal:33-34

Apriliani Fitriana Yunus. 2015. Potensi Ekstrak Daun Timo (Kleinhovia hospital) Sebagai Antioksidan Dan Antihiperlipidemia : Metode DPPH Dan Penghambatan Lipase In Vitro. Fakultas Farmasi Universitas Jember. Jember, Hal:8

Septian Markus. 2010. Pengaruh Pemberian Ekstrak Labu Siam (Sechium edule ) Jaq.) Sw.) Terhadap Kadar Trigliserida Darah Tikus Putih (Rattus norvegicus) Yang Diinduksi Dengan Pemberian Pakan Hiperkolesterolemik. Fakultas Kedokteran Universitas Sebelas Maret. Surakarta, Hal:19-20

Nagata Junichi, Morino Tomoko dan Saito Morlo. 2007. Effects od Fietary Angelica keiskei on Serum and Liver Lipid Profile, adn Body Fat Accumulation in Rats. J Nutr Sci Vitaminol, 54, 133-137. Tokyo, Hal:2

Sudarmika I Wayan dan Jawi I Made. 2012. Ekstrak Air Daun Ubijalar Ungu Memperbaiki Profil Lipid Dan Meningkatkan Kadar SOD Darah Tikus Yang Diberi Makanan Tinggi Kolesterol. Jurnal Ilmiah Kedokteran, Medicina volume 43 nomor 2. Bali, hal:1-2

Arief M. Iqbal Dkk. 2012. Potensi Bunga Karamunting (Melastoma Malabathricum L.) Terhadap Kadar Kolesterol Total Dan Trigliserida Pada Tikus Putih Jantan Hiperlipidemia Yang Diinduksi Propiltiourasil. Prestasi, Volume 1, Nomor 2. Banjarmasin, Hal:2

Katzung Bertram G., Masters Susan B., Trevor AnthonyJ. 2014. Farmakologi Dasar & Klinik Vol. 2 Edisi 12, Penerbit Buku Kedokteran EGC. Jakarta.




DOI: http://dx.doi.org/10.30742/jikw.v6i2.57

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Copyright (c) 2017 Cecilia Febriani Marentek, Ernawati Ernawati

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Jurnal Ilmiah Kedokteran Wijaya Kusuma 

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