Pengaruh Ekstrak Undur-undur (Myrmeleon sp) terhadap Glukosa Darah dan Hematokrit pada Tikus Diabetes

Djap Hadi susanto, Ronald Winardi Kartika, Pamela Hendra Heng, Adit Widodo Santoso, Maria VB Lopulalan, Angelina Wijaya


Diabetes Mellitus (DM) is one of the major health problems in the world and Indonesia. The prevalence is more increasing and also shows the trend of events is shifting to young age. Diabetes mellitus treatment requires high costs and also a lifetime. Most of the people of Indonesia still use traditional methods of treatment, especially herbs from various biological substances that are available in the environment. Undur-undur (myrmeleon sp.) is believed to have the effect of anti-hyperglycemia, and also anti-viscosity. The aim of this study was to determine anti-hyperglycemia and anti-viscosity of myrmeleon sp. extract in diabetic rats. The design of study is randomized experiment. Diabetic rats were induced by streptozocin 100mg/ kg BW intraperitoneal. Fifty rats were divided into 2 groups administered by Myrmeleon sp. extract dose 0,01ml/ 200 gram BW (100%) and 0,005ml/ 200 gram BW (50%). Myrmeleon sp. shows the effect of anti-hyperglycemic and anti-viscosity in diabetic rats. There was a difference between 50% and 100% doses. The effect of anti-hyperglycemia and anti-viscosity occurs after the second day. Conclusion: the extract of myrmeleon sp. could be considered as one of the traditional treatments of diabetic patients.


myrmeleon sp.; diabetes mellitus; glukosa darah; hematokrit.

Full Text:



Afsar HA, and Younus M, 2004. Patient Referral at the Grass-Roots Level in Pakistan. Nature and Science. 2(4): 18-27.

Badan Litbangkes Depkes RI, 2010. Riset kesehatan dasar 2010.

Badan Litbangkes Depkes RI, 2013. RISET KESEHATAN DASAR.

Dewi MR, 2014. Undur-undur darat (Myrmeleon sp.) sebagai Obat Alternatif Diabetes Melitus. Jurnal Ilmu Peternakan.

Djap HS, Sutrisna B, Soewondo P, Djuwita R, Timotius KH, et al, 2018. Waist to Height Ratio (0.5) as a Predictor for Prediabetes and Type 2 Diabetes in Indonesia. IOP Conference Series: Materials Science and Engineering. IOP Publishing, 434: 12311.

Huber CA, Schwenkglenks M, Rapold R and Reich O, 2014. Epidemiology and Costs of Diabetes Mellitus in Switzerland: An Analysis of Health Care Claims Data, 2006 and 2011. BMC Endocrine Disorders. 14(1): 1–9.

Irace C, Scarinci F, Scoria V, Bruzzichessi D, Fiorentino R, et al, 2011. Association among Low Whole Blood Viscosity, Haematocrit, Haemoglobin and Diabetic Retinopathy in Subjects with Type 2 Diabetes. British Journal of Ophthalmology. 95(1): 94–98.

Kurniasih T, Isma'il M, Susilowati F, dan Lestari SP, 2015. Kajian potensi undur-undur darat (Myrmelon sp.) sebagai antidiabetes. PKMP-2-8-1

Kurniasih T, Isma'il M, Susilowati F, Lestari SP, 2006. Kajian potensi undur-undur darat (Myrmeleon sp) sebagai antidiabetes. thesis. Fakultas Biologi, Universitas Gadjah Mada, Yogyakarta.

Muadifah A, Sulistyarti H, and Prasetyawan S, 2017. Liquid Chromatography for Analysis of Metformin in Myrmeleon sp. The Journal of Pure and Applied Chemistry Research. 6(3): 196–206.

Mujahid ZM, 2013. A Combination of Bitter Gourd Ethanolic Extract with Ant Lion Larvae Aqueous Extract for a Blood Glucose-Lowering Agent. IFRJ. 20(2): 851–855.

Narulita E, Iqbal M, Surakhman G, 2019. A Novel Antibacterial Agent of Myrmeleon formicarius Extract for Diabetic Ulcer Infection. Indonesian Journal of Biotechnology and Biodiversity. 3(2): 48-54.

PB Perkeni, 2015. Pengelolaan dan pencegahan diabetes melitus tipe 2 di indonesia 2015.

Prihatin J, Narulita E, Mufidah L, Kurniawan A, Wulandari D, et al, 2019. Antihyperglycaemic And Tissue-Repair Effects of Myrmeleon Formicarius Extract in Streptozotocin-Induced Diabetic Mice. Journal of Taibah University Medical Sciences. 14(2): 149–155.


ahma HH, Sundhani E, and Nurulita NA, 2016. Antidiabetic Activity of Powder and Ethanolic Extract of Antlion (Myrmeleon Sp.) on Wistar Strain White Male Rats with Glucose Preload. Proceeding ICMHS. 2016: 14–16.

Soegondo S, 2008. Apakah penyakit dabetes melitus itu?’, in Hidup secara mandiri dengan diabetes melitus kencing manis sakit gula. Balai Penerbit FKUI: 1–11.

Sudharsanan N, Ali MK, Mehta NK, and Narayan KMV, 2015. Population Aging, Macroeconomic Changes, and Global Diabetes Prevalence, 1990-2008, Population Health Metrics. 13(1): 1–8.

Sutanto F, 2008. Daya Hambat Ekstrak Metanol Undur-Undur terhadap Aktivitas Enzim Α-Glukosidase sebagai Antidiabetes. Skripsi. Institut Pertanian Bogor.

Tamariz LJ, Young JH, Pankow JS, Yeh HC, Schmidt MI, Astor B, and Brancati FL, 2008. Blood Viscosity and Hematocrit as Risk Factors for Type 2 Diabetes Mellitus: The Atherosclerosis Risk in Communities (ARIC) Study. American Journal of Epidemiology. 168(10): 1153–1160.

Tulloch-Reid MK, Hanson RL, Saremi A, Looker HC, Williams DE, et al, 2004. Hematocrit and the Incidence of Type 2 Diabetes in the Pima Indians. Diabetes Care. 27(9): 2245–2246.

Wang W, Lee ET, Howard BV, Fabsitz RR, Devereux RB, et al, 2011. Fasting Plasma Glucose and Hemoglobin A1C in Identifying and Predicting Diabetes: The Strong Heart Study. Diabetes Care. 34(2): 363-368.

Whiting DR, Guariguata L, Weil C, and Shaw J, 2011. IDF Diabetes Atlas: Global Estimates of the Prevalence of Diabetes for 2011 and 2030. Diabetes Research and Clinical Practice. 94(3): 311–321.



  • There are currently no refbacks.

Copyright (c) 2020 Djap Hadi susanto

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.



Jurnal Ilmiah Kedokteran Wijaya Kusuma 

ISSN: 1978-2071(print); 2580-5967 (online)
Published by the Institute for Research and Community Services (LPPM) of University of Wijaya Kusuma Surabaya.
Surabaya, Indonesia
Creative Commons License
All publications by Jurnal Ilmiah Kedokteran Wijaya Kusuma are licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
counter View My Stats