Pengaruh Spirulina terhadap Kadar beta hCG Tikus Bunting yang Diinduksi Interleukin-6 (Studi Bahan Biologis Tersimpan)

Harry K Gondo, Elizabeth Haryanti

Abstract


Preeclampsia is multisystem specific disorder in pregnancy. Preeclampsia characterized by increased cytokine Interleukin-6 and β hCG (human Chorionic Gonadotropin). Spirulina is green-blue alga contain antioxidant, vitamin, mineral. Spirulina has a potential effect as antiinflammation. The aim of this research was to know effect of spirulina to repair trophoblast at β hCG level of pregnant rats with preeclampsia condition (biology material collecting). The type of this research is an experimental laboratory with post-test only control group design. Preeclampsia models induced by Interleukin-6. Twenty-five rats were grouped to five group: Control, Control Positive, Spirulina dose 10, 20, and 40 mg/day, at the end of treatment, β hCG level were analyzed. Statistical analysis was used by one-way ANOVA. The results of this study showed that β hCG level of group spirulina dose 10 mg/day (85.11 ± 25.70 mIU/ml) did not significantly different (p=0.353), with group Dose 20 mg/day (79.65 ± 10.65 mIU/ml). Level of β hCG in Spirulina group dose 40 mg/day were 93.28 ± 17.12 mIU/ml. The spirulina groups dose 10 mg/day and dose 40 mg/day did not show significantly different level of β hCG (0.730> 0.05). Administration of spirulina at a dose of 10 mg was able to significantly reduce levels of β hCG (P <0.05) than at doses of 20 mg / day and 40 mg/ day.


Keywords


Preeklampsia; Interleukin 6; β hCG, Spirulina

Full Text:

PDF

References


Arylza IS, 2005. Phycocyanin dari Mikroalga Bernilai Ekonomis Tinggi sebagai Produk Industri. Oseana. 3(3): 27-36.

Asghari A, et al 2016. A review on antioxidant properties of Spirulina. Journal of Applied Biotechnology Reports. 3(1): 345–351.

Belay A, 2002. The Potential Application of Spirulina (Arthrospira) as a Nutritional and Therapeutic Supplement in Health Management. The Journal of the American Nutraceutical Association Vol 5, no 2, Spring.

Choudhury 2012, Value of Serum β-hCG in Pathogenesis of Pre-Eclampsia. Journal of Clinical Gynecology and Obstetrics. 1: 71–75.

Chuppana R, Madhavi AP, Sharon PS, Priya SS, Shehnaz S, 2018. A study of maternal deaths from preeclampsia and eclampsia in a tertiary care centre. IAIM. 5(1): 6–10.

Emzir. 2007. Metodologi Penelitian Pendidikan Kuantitatif dan Kualitatif. Jakarta: PT Raja Grafindo Persada.

Gadonski G. 2006. Hypertension Produced by Reductions in Uterine Perfusion in the Pregnant Rat Role of Interleukin-6. Departments of Physiology and Obstetrics–Gynecology and Center for Excellence in Cardiovascular–Renal Research, University of Mississippi Medical Center, Jackson, Miss.pages 711-715.

Gökdeniz R, Ariguloglu R, Bazoglu N, Balat O, 2000. Elevated serum b-hCG levels in severe preeclampsia. Turk. J. Med. Sci. 30(2000): 43-45.

Mihu D, Razvan C, Malutan A, Mihaela C, 2015. Evaluation of maternal systemic inflammatory response in preeclampsia. Taiwanese Journal of Obstetrics and Gynecology. 54(2): 160–166.

Norris W, Nevers T, Sharma S, Kalkunte S, 2011. Review: hCG, Preeclampsia and Regulatory T cells. Placenta. 32(suppl 2): S182-S185.

Oliveira EG, Rosa GS, Moraes MA, Pinto LAA. 2008. Phycocyanin Content of Spirulina platensis dried in spouted bed and thin layer. Journal of Food Process Engineering, 31(1): 34-50.

Priyatini T, Wiknjosastro GH. 2004. Angka Kejadian Preeklampsia Berat dan Eklampsia di Rumah Sakit Umum Pusat Cipto Mangunkusumo Jakarta.

Ravi M, De SL, Azharuddin S, Paul SFD, 2010. The beneficial effects of spirulina focusing on its immunomodulatory and antioxidant properties. Nutrition and Dietary Supplements. 2: 73-83.

Say L, Chou D, Gemmill A, Tuncalp O, Moller Ann-Beth et al, 2014. Global causes of maternal death: A WHO systematic analysis. The Lancet Global Health. 2(6): 323–333.

Sotler R, Poljsak B, Dahmane R, Jukic T, Jukic DP et al, 2019. Prooxidant Activities of Antioxidants and Their Impact on Health. Acta Clin Croat. 58: 726-736.

Sujiyatini, dkk. 2009. Asuhan Patologi Kebidanan. Nuha Medika, Jakarta.




DOI: http://dx.doi.org/10.30742/jikw.v10i1.1067

Refbacks

  • There are currently no refbacks.


Copyright (c) 2021 Harry K Gondo, Elizabeth Haryanti

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Jurnal Ilmiah Kedokteran Wijaya Kusuma is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License