Perbedaan Kadar Leukosit dan Limfosit Paska Pemberian Kombinasi Vitamin B Parenteral Pada Pasien Penyakit Ginjal Kronik dengan Hemodialisis

Rizaldy Taslim Pinzon, Ester Novitasari, Nining Sri Wuryaningsih

Abstract


Chronic kidney disease is a disease in which kidney function decreases progressively irreversibly with various etiologies. Patients with chronic kidney disease are generally immunosuppressed and susceptible to infection. Some of the causes are abnormalities in polymorphonuclear leukocytes and lymphocytes. The results of several studies indicate that patients undergoing hemodialysis have low levels of water-soluble vitamins. A decrease in the number of leukocytes can also occur due to a decrease in neutrophils and lymphocytes which may be caused by deficiency of vitamins B6 and B12 due to hemodialysis. This study aims to measure the difference in levels of leukocytes and lymphocytes after parenteral vitamin B combination administration in patients with chronic kidney disease undergoing hemodialysis This research is a quasi-experimental design, One Group Pretest Posttest, on 115 selected patients. Patients were given vitamin B1 ,B6 ,B12 parenterally every time doing hemodialysis, twice a week given for 1 month during hemodialysis. The data were taken in the form of leukocyte count, patient lymphocyte percentage, and absolute lymphocyte concentration. The intervention of vitamins B1, B6, B12 was given parenterally to the patient. After collect the data, the leukocyte counts, lymphocyte percentage and absolute lymphocyte concentration before and after the intervention were seen, then it was seen how the effect of parenteral administration of vitamins B1 ,B6 ,B12 on the leukocyte count, lymphocyte percentage and absolute lymphocyte concentration in patients undergoing hemodialysis. From the results of the study, there were 115 patients consisted of 72 men (62.6%) and 43 women (37.4%). There was a difference and effect of giving combination vitamin B in the form of a significant change in the mean number of leukocytes at visits 1-2 with p-value = 0.033. There was a change in the mean of lymphocyte percentage and absolute lymphocyte concentration after administering vitamins B1, B6 ,B12 , but the changes were not significant.


Keywords


chronic kidney disease; deficiency of vitamins B1, B6, B12; changes in levels of leukocytes and lymphocytes

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References


Suwitra K, 2014. Penyakit Ginjal Kronik. In: S. Setiati, I. Alwi, A. Sudoyo, M. Simadibrata, B. Setiyohadi and A. Syam, ed., Buku Ajar Ilmu Penyakit Dalam Jilid II, 6th ed. Jakarta: InternaPublishing, pp.2161-2167.

Luyckx V, Tonelli M, Stanifer J, 2018. The global burden of kidney disease and the sustainable development goals. WHO.

Cavanaugh K, Ikizler T, 2016. Chronic Kidney Disease. In: I. Benjamin, R. Griggs, E. Wing and J. Fitz, ed., Andreoli and Carpenter's Cecil Essentials of Medicine, 9th ed. Elsevier, Philadelphia.

Abbas A, Lichtman A, Pillai S, 2016. Imunologi Dasar Abbas: Fungsi dan Kelainan Sistem Imun. 5th ed. Elsevier, Singapore.

Ross A, Caballero B, Cousins R, Tucker K, Ziegler T, 2014. Modern Nutrition in Health and Disease. 11th ed. Lippincott Williams & Wilkins, Philadelphia.

Mikkelsen K, Stojanovska L, Prakash M, Apostolopoulos V, 2017. The effects of vitamin B on the immune/cytokine network and their involvement in depression. Maturitas. 96:58-71.

Wilson C, Vergara-Lluri M, Brynes R, 2017. Evaluation of Anemia, Leukopenia, and Thrombocytopenia. In: E. Jaffe, D. Arber, E. Campo, N. Harris and a. Quintanilla-Martinez, ed., Hematopathology, 2nd ed. Elsevier, Philadelphia. 195-234.

Carrero J, Hecking M, Chesnaye N, Jager K, 2018. Sex and gender disparities in the epidemiology and outcomes of chronic kidney disease. Nature Reviews Nephrology. 14(3):151-164.

Chang P, Chien L, Lin Y, Wu M, Chiu W, Chiou H, 2016. Risk factors of gender for renal progression in patients with early chronic kidney disease. Medicine. 95(30):p.e4203.

Elia M, Ljungqvist O, Stratton R, Lanham-New S, 2013. Clinical nutrition. 2nd ed. Wiley-Blackwell, John Wiley & Sons, Oxford.

Brenner BM, Lazarus JM, 2012. Gagal Ginjal Kronik. In: Isselbacher, K., Braunwald, E., Wilson, J., Martin, J., Fauci, A. and Kasper, D., ed., Harrison: Prinsip-Prinsip Ilmu Penyakit Dalam Volume 3, 13th ed. EGC, Jakarta. 1435-1443.

Wolfson A, 2018. Renal Failure. In: R. Walls, R. Hockberger and M. Gausche-Hill, ed., Rosen's Emergency Medicine: Concepts and Clinical Practice, 9th ed. Elsevier, Philadelphia. 1179-1196.

Dalrymple L, Go A, 2008. Epidemiology of Acute Infections among Patients with Chronic Kidney Disease. Clinical Journal of the American Society of Nephrology. 3(5):1487-1493.

Saad K, Elsayh K, Zahran A, Sobhy K, 2014. Lymphocyte populations and apoptosis of peripheral blood B and T lymphocytes in children with end stage renal disease. Renal Failure. 36(4):502-507.

Atziza R, Ayu P, Yonata A, 2017. Perbedaan Kadar Limfosit Pre dan Post Hemodialisis Pasien Gagal Ginjal Kronik. Medula.

Lisowska K, Dębska-Ślizień A, Jasiulewicz A, Bryl E, Witkowski J, 2013. Influence of hemodialysis on circulating CD4lowCD25high regulatory T cells in end-stage renal disease patients. Inflammation Research. 63(2):99-103.

Metz T, Alderson N, Thorpe S, Baynes J, 2003. Pyridoxamine, an inhibitor of advanced glycation and lipoxidation reactions: a novel therapy for treatment of diabetic complications. Archives of Biochemistry and Biophysics. 419(1):41-49.

Maggini S, Wintergerst ES, Beveridge S, Hornig DH, 2007. Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses. British Journal of Nutrition. 98(S1):S29–S35.

Lewicki S, Lewicka A, Kalicki B, Kłos A, Bertrandt J, Zdanowski R. 2014. Experimental immunology The influence of vitamin B 12 supplementation on the level of white blood cells and lymphocytes phenotype in rats fed a low-protein diet. Central European Journal of Immunology. 419-425.

Stopper H, Treutlein AT, Bahner U, Schupp N, Schmid U, Brink A, et al, 2008. Reduction of the genomic damage level in haemodialysis patients by folic acid and vitamin B12 supplementation. Nephrology Dialysis Transplantation. 23(10):3272–3279.

Stenvinkel P, 2003. Anaemia and inflammation: what are the implications for the nephrologist? Nephrology Dialysis Transplantation.

Hasdinah HR, Dewi P, Peristiowati Y, Imam S, 2014. Imunologi - Diagnosis dan Teknik Biologi Molekuler. Nuha Medika, Yogyakarta.




DOI: http://dx.doi.org/10.30742/jikw.v10i1.1083

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Jurnal Ilmiah Kedokteran Wijaya Kusuma 

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