The Role of Cytokines in Inflammatory Process of Knee Osteoarthritis: Systematic Review

Florencia Christofora Ngantung, Basuki Supartono, Hikmah Muktamiroh


Osteoarthritis (OA) is a degenerative joint disorder that occurs in cartilage. OA is the main cause of disability in adults and generally characterized by pain to the joints that got pressured. Based on several previous studies, it is known that the incidence of osteoarthritis is correlated with synovial inflammation and that inflammatory cytokines play an important role in the expansion of osteoarthritis. Based on these things, the author intends to conduct a literature study with the aim of knowing the role of cytokines on inflammation in knee osteoarthritis. The research was conducted through PubMed and Science Direct databases. The results of the study showed that cytokines played negative different roles depending on the type of cytokines such as those found in knee OA inflammation. Conclusion: Cytokines have a negative effect because they can disrupt synovial tissue balance, induce catabolic processes, and induce osteoclast differentiation and subchondral bone resorption.


Ostearthritis, Cytokines, Inflammation, Synovial

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Abramoff, B., & Caldera, F. E. (2020). Osteoarthritis: Pathology, Diagnosis, and Treatment Options. The Medical Clinics of North America, 104(2), 293–311.

Bastiaansen-Jenniskens, Y., Saris, D. B. F., & Creemers, L. (2017). Pro- and Anti-inflammatory Cytokine Profiles in Osteoarthritis. In Cartilage: Volume 2: Pathophysiology (pp. 81–97).

Chow, Y. Y., & Chin, K.-Y. (2020). The Role of Inflammation in the Pathogenesis of Osteoarthritis. Mediators of Inflammation, 2020, 8293921.

de Lange-Brokaar, B. J. E., Ioan-Facsinay, A., van Osch, G. J. V. M., Zuurmond, A.-M., Schoones, J., Toes, R. E. M., Huizinga, T. W. J., & Kloppenburg, M. (2012). Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review. Osteoarthritis and Cartilage, 20(12), 1484–1499.

Deligne, C., Casulli, S., Pigenet, A., Bougault, C., Campillo-Gimenez, L., Nourissat, G., Berenbaum, F., Elbim, C., & Houard, X. (2015). Differential expression of interleukin-17 and interleukin-22 in inflamed and non-inflamed synovium from osteoarthritis patients. Osteoarthritis and Cartilage, 23(11), 1843–1852.

Favero, M., Belluzzi, E., Trisolino, G., Goldring, M. B., Goldring, S. R., Cigolotti, A., Pozzuoli, A., Ruggieri, P., Ramonda, R., Grigolo, B., Punzi, L., & Olivotto, E. (2019). Inflammatory molecules produced by meniscus and synovium in early and end-stage osteoarthritis: a coculture study. Journal of Cellular Physiology, 234(7), 11176–11187.

Kohn, M. D., Sassoon, A. A., & Fernando, N. D. (2016). Classifications in Brief: Kellgren-Lawrence Classification of Osteoarthritis. Clinical Orthopaedics and Related Research, 474(8), 1886–1893.

Kolasinski, S. L., Neogi, T., Hochberg, M. C., Oatis, C., Guyatt, G., Block, J., Callahan, L., Copenhaver, C., Dodge, C., Felson, D., Gellar,

K., Harvey, W. F., Hawker, G., Herzig, E., Kwoh, C. K., Nelson, A. E.,

Samuels, J., Scanzello, C., White, D., … Reston, J. (2020). 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee. Arthritis Care & Research, 72(2), 149–162.

Mabey, T., & Honsawek, S. (2015). Cytokines as biochemical markers for knee osteoarthritis. World Journal of Orthopedics, 6(1), 95–105.

Martel-Pelletier, J., Barr, A. J., Cicuttini, F. M., Conaghan, P. G., Cooper, C., Goldring, M. B., Goldring, S. R., Jones, G., Teichtahl, A. J., & Pelletier, J.-P. (2016). Osteoarthritis. Nature Reviews. Disease Primers, 2, 16072.

Molnar, V., Matišić, V., Kodvanj, I., Bjelica, R., Jeleč, Ž., Hudetz, D., Rod, E., Čukelj, F., Vrdoljak, T., Vidović, D., Starešinić, M., Sabalić, S., Dobričić, B., Petrović, T., Antičević, D., Borić, I., Košir, R., Zmrzljak, U. P., & Primorac, D. (2021). Cytokines and Chemokines Involved in Osteoarthritis Pathogenesis. International Journal of Molecular Sciences, 22(17).

Nees, T. A., Rosshirt, N., Reiner, T., Schiltenwolf, M., & Moradi, B. (2019). [Inflammation and osteoarthritis-related pain]. Schmerz (Berlin, Germany), 33(1), 4–12.

Newberry, S. J., FitzGerald, J., SooHoo, N. F., Booth, M., Marks, J., Motala, A., Apaydin, E., Chen, C., Raaen, L., Shanman, R., & Shekelle, P. G. (2017). No Title.

Saberi Hosnijeh, F., Bierma-Zeinstra, S. M., & Bay-Jensen, A. C. (2019). Osteoarthritis year in review 2018: biomarkers (biochemical markers). Osteoarthritis and Cartilage, 27(3), 412–423.

Supartono, B., Hutagalung, E., Boediono, A., Shirakawa, T., & Djauzi, S. (2018). Hyaline Cartilage Regeneration on Osteochondral Defects by Intraarticular Injection of Human Peripheral Blood CD 34 + Stem Cells , Hyaluronic Acid and Growth Factor In a Rat Model. 5(4), 5617–5626.

van den Bosch, M. H. J. (2019). Inflammation in osteoarthritis: is it time to dampen the alarm(in) in this debilitating disease? Clinical and Experimental Immunology, 195(2), 153–166.

Zhu, Z., Otahal, P., Wang, B., Jin, X., Laslett, L. L., Wluka, A. E., Antony, B., Han, W., Wang, X., Winzenberg, T., Cicuttini, F., Jones, G., & Ding, C. (2017). Cross-sectional and longitudinal associations between serum inflammatory cytokines and knee bone marrow lesions in patients with knee osteoarthritis. Osteoarthritis and Cartilage, 25(4), 499–505.



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