Clinical Manifestation of Childhood Diphtheria
Abstract
Even though diphtheria vaccination has been routinely done all around the world, some of developing country still reported outbreak. Indonesia declared diphtheria outbreak in 2017. Diphtheria is characterized by sore throat, fever and the formation of pseudo-membrane located in the tonsils, pharynx or nasal cavity. Diphtheria is very common in children. This study was conducted to determine the clinical picture of diphtheria in children at Sulianto Saroso Infectious Disease Hospital January 2018 - December 2018. The study was descriptive cross – sectional using medical records of diphtheria patients for the period January 2018 – December 2018. The sample is 141 diphtheria patients with the total sampling method. Data analysis using univariate. In this study, out of 141 children with diptheria, the highest number of cases was recorded boy (58,2%), among 6-11 years old, and fully vaccinated (60.3%). Most patient complained about sore throat (95%), fever (93.6%), and bullneck (32.6%). Majority of diphtheria patients with bilateral tonsillar membranes were also found (71.6%), followed by the majority of negative culture results (66.7%), experienced no complications (78.7%), and discharge (99.3%). Clinical characteristic that commonly appeared were sore throat, fever, and bilateral tonsillar membrane. We found it is important to diagnose and treat early to prevent complication and mortality.
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Alfiansyah, G. (2015). Epidemiological Investigation of Diphtheria ’ s Outbreak at Blitar District in 2015. The Indonesian Journal of Public Health, 4.
Arguni, E., Karyanti, M. R., Satari, H. I., & Hadinegoro, S. R. (2021). Diphtheria outbreak in Jakarta and Tangerang, Indonesia: Epidemiological and clinical predictor factors for death. PLoS ONE, 16(2 February). https://doi.org/10.1371/journal.pone.0246301
Arifin, I. F., & Prasasti, C. I. (2017). Factors That Related With Diptheria Cases of Children in Bangkalan Health Centers in 2016. Jurnal Berkala Epidemiologi, 5(1), 26. https://doi.org/10.20473/jbe.v5i1.2017.26-36
Arya, P., Maharia, M. S., Kadela, R. K., & Deepchand. (2022). A Clinical Study of Complications of Diphtheria. International Journal of Medical and Biomedical Studies, 6(3), 1052–1055. https://doi.org/10.32553/ijmbs.v6i3.2476
Dyah Nugroho, A. P., Hidayati, D., Montain, M. M., Wijiarti, K., & Murtiani, F. (2019). Gambaran Karakteristik Dan Pemberian Anti Difteri Serum (ADS) Pada Pasien Difteri Di Rumah Sakit Penyakit Infeksi Prof. Dr. Sulianti Saroso Tahun 2014-2016. The Indonesian Journal of Infectious Diseases, 5(1), 18.
https://doi.org/10.32667/ijid.v5i1.62
Fischinger, S., Boudreau, C. M., Butler, A. L., Streeck, H., & Alter, G.
(2019). Sex differences in vaccine-induced humoral immunity. In Seminars in Immunopathology (Vol. 41, Issue 2, pp. 239–249). Springer Verlag. https://doi.org/10.1007/s00281-018-0726-5
Hadinegoro, S. R. S., Moedjito, I., Hapsari, D., & Alam, A. (2018). Buku Ajar Infeksi & Penyakit Tropis (2nd ed). IDAI.
Harsanti, E. A., Setiabudi, D., & Wijaya, M. (2020). Hubungan Status Imunisasi dengan Kejadian Difteri Berat pada Pasien Anak yang Dirawat di Rumah Sakit Umum Pusat Dr. Hasan Sadikin Bandung Periode Januari 2015 – Juli 2019. Sari Pediatri, 21(5), 317. https://doi.org/10.14238/sp21.5.2020.317-21
Harwalkar, K. K., & Kadegaon, B. (2019). Clinical profile of children with diphtheria admitted to tertiary care center. Indian Journal of Child Health, 6(10), 563–565.
Jammar, S. K., Kataria, T., Agarwal, S., Sharma, S., Meena, R., Singh, S. N., Harshvardhan, R., & Gupta, A. (2021). An Observational Study on Association of Clinical Diagnosis of Diphtheria with Smear and Culture Test: A Tertiary Care Hospital, Jaipur. Indian Journal of Otolaryngology and Head and Neck Surgery. https://doi.org/10.1007/s12070-021-02661-2
Kemenkes RI. (2020). Profil Kesehatan Indonesia Tahun 2020.
Kolybo, D. V. (2013). Immunobiology of Diphtheria. Recent Approaches for the Prevention, Diagnosis, and Treatment of Disease. Biotechnologia Acta, 6(4), 43–62. https://doi.org/10.15407/biotech6.04.043
Liansyah, T. M., Safri, M., & Yusuf, S. (2020). Hubungan Karakteristik Klinis dan Laboratoris Terhadap Kejadian Miokarditis Difteri pada Anak di RSUD Dr. Zainoel Abidin Banda Aceh. Sari Pediatri, 22(3), 131. https://doi.org/10.14238/sp22.3.2020.131-8
Meera, & Rajarao. (2014). Diphtheria in Andhra Pradesh-a clinical-epidemiological study. International Journal of Infectious Diseases: IJID : Official Publication of the International Society for Infectious Diseases, 19, 74–78. https://doi.org/10.1016/j.ijid.2013.10.017
Nawing, H. D., Pelupessy, N. M., Alimadong, H., & Albar, H. (2019). Clinical spectrum and outcomes of pediatric diphtheria. Paediatrica Indonesiana, 59(1), 38–43. https://doi.org/10.14238/pi59.1.2019.38-43
Quick, M. L., Sutter, R. W., Kobaidze, K., Malakmadze, N., Nakashidze, R., Murvanidze, S., Wooten, K. G., & Strebel, P. M. (2000). Risk factors for diphtheria: A prospective case-control study in the Republic of Georgia, 1995-1996. Journal of Infectious Diseases, 181(SUPPL. 1), 1995–1996. https://doi.org/10.1086/315563
Tosepu, R., Gunawan, J., Effendy, D. S., Ahmad, L. O. A. I., & Farzan, A. (2018). The outbreak of diphtheria in Indonesia. Pan African Medical Journal, 31, 1–5. https://doi.org/10.11604/pamj.2018.31.249.16629
DOI: http://dx.doi.org/10.30742/jikw.v12i1.2468
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