Wide Margin Excision in Patients with Giant Condyloma Acuminata

Lucky Pratama, Lita Setyowatie, Diah Prabawati Retnani


Giant condyloma acuminata (GCA) is one of sexually transmitted infections caused by the Human Papilloma Virus (HPV) infection, specifically HPV types 6 and 11. Giant condyloma acuminata is a rare disease with an incidence of around 0.1%. The age distribution peaked in 25-29 years. The higher prevalence of infection is associated with number of sexual partners, history of chlamydia and gonorrhea infection, smoking and human immunodeficiency virus (HIV) infection. A 24 years old male presented with a cauliflower-like mass on the penis that has been growing slowly for 2 years. Physical examination of the penis revealed a pedunculated reddish verrucous mass, mobile, well-defined, 5x2x1.5 cm in size, and positive acetowhite test. The histopathological picture is in accordance with condyloma acuminata. Surgery with wide margin excision was performed to remove the lump. After 14 days post-surgery, the wound was healed completely without any sign of recurrence.


giant condyloma acuminata, wide margin excision, Human papilloma virus

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Chan, M. P. (2019). Verruciform and condyloma-like squamous proliferations in the anogenital region. Archives of Pathology & Laboratory Medicine, 143(7), 821-831.

Chen, X., Zhou, Y., Tan, Y., Duan, G., Li, Z., Zou, P., ... & Zhan, Y. (2020). Successful management of giant condyloma acuminatum of vulva with the combination of surgery and photodynamic therapy: report of two cases. Photodiagnosis and Photodynamic Therapy, 31, 101847.

Clanner-Engelshofen, B. M., Marsela, E., Engelsberger, N., Guertler, A., Schauber, J., French, L. E., & Reinholz, M. (2020). Condylomata acuminata: A retrospective analysis on clinical characteristics and treatment options. Heliyon, 6(3), e03547.

Fathi, R., & Tsoukas, M. M. (2014). Genital warts and other HPV infections: established and novel therapies. Clinics in dermatology, 32(2), 299-306.

Hastuti, R., Mustifah, E. F., & Ellistasari, E. Y. (2018). Kombinasi Krioterapi dan KOH 5% untuk Terapi Kondiloma Akuminata Raksasa dengan Infeksi HIV. Cermin Dunia Kedokteran, 45(7), 542-527.

Jovic, A., Kocic, H., Damiani, G., Popovic, D., Vidovic, N., Radevic, T., ... & Tiodorovic, D. (2020). Unusual Clinical Presentation of Giant Extragenital Condyloma. Acta Dermatovenerologica Croatica, 28(4), 240-241.

Loo, G. H., Lim, L. Y., Zainuddin, Z. M., & Fam, X. I. (2019). Staged resection in the management of HIV-related anogenital giant condyloma acuminatum. A case report. Annals of Medicine and Surgery, 48, 73-76.

Mandel, A., Reese, A., Nasibili, J., & Mydlo, J. H. (2022). Radical excision of inguinal condyloma acuminatum following 51 years of untreated growth, found to be squamous cell carcinoma. Urology Case Reports, 40, 101937.

Nieves-Condoy, J. F., Acuña-Pinzón, C. L., Chavarría-Chavira, J. L., Hinojosa-Ugarte, D., & Zúñiga-Vázquez, L. A. (2021). Giant condyloma acuminata (Buschke-Lowenstein Tumor): review of an unusual disease and difficult to manage. Infectious Diseases in Obstetrics and Gynecology, 2021.

Pineda-Murillo, J., Lugo-García, J. A., Martínez-Carrillo, G., Torres-Aguilar, J., Viveros-Contreras, C., & Schettino-Peredo, M. V. (2019). Buschke–Löwenstein tumor of the penis. African Journal of Urology, 25(1), 1-4.

Purzycka-Bohdan, D., Szczerkowska-Dobosz, A., Swiatecka-Czaj, J., Peksa, R., Urban, M., Szczypior, M., & Nowicki, R. (2019). Buschke-Löwenstein tumour associated with low-risk human papillomavirus genotypes successfully treated surgically. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 36(1), 112-114.

Rohanda, B. A., Hutapea, R., & Nadeak, K. (2021). Identification of the type of Human Papilloma Virus (HPV) in condyloma acuminata in the genital and/or anal areas in men who have sex with men (MSM). Bali Medical Journal, 10(2), 885-890.

Sebastián, A. A., Vicente, F. P., Paz, P. S., Navarro, D. C., Frías, A. F., Romero, A. S., ... & Polo, F. C. (2003). Infiltrative squamous-cell carcinoma arising in perianal buschke-lowenstein tumour: Successful treatment with surgical excision. Revista de Oncología, 5(5), 291-293.

Skowrońska-Piekarska, U., & Kościński, T. (2015). Buschke-Loewenstein tumor resection with simultaneous reconstruction of extensive tissue losses: case report. BMC surgery, 15(1), 1-4.

Thakor, P., Badgurjar, M. K., Prajapati, G., Saxena, P., & Parihar, S. (2021). Giant Genital Condyloma Acuminatum: A case report.

Venter, F., Heidari, A., Viehweg, M., Rivera, M., Natarajan, P., & Cobos, E. (2018). Giant condylomata acuminata of Buschke-Lowenstein associated with paraneoplastic hypercalcemia. Journal of Investigative Medicine High Impact Case Reports, 6, 2324709618758348.

DOI: http://dx.doi.org/10.30742/jikw.v12i1.2643


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