Analysis of Factors Influencing Mortality in Patients with Intracerebral Hemorrhagic Stroke
Abstract
Stroke is a cerebrovascular disease that causes sudden neurological deficits due to the interruption of blood supply to the brain, resulting in the disruption of brain function. It is ranked as the second most common cause of death worldwide and leads to the highest number of disabilities globally. The incidence of this disease is 10-20 cases per 100,000 population, reaching 15% of all strokes worldwide yearly. The highest mortality rate was 20.3% after 48 hours and 18.3% less than 48 hours. This number is greater than the death rate in stroke infarction. This study aims to analyze the factors influencing mortality in patients with intracerebral hemorrhage (ICH). This type of research is observational analytic research. The design used is cross-sectional. This study was approved by the Health Ethics Committee of the Jemursari Islamic Hospital in Surabaya. The sampling technique uses total sampling. The total sample of this study was 65 patients. The sample in this study were all ICH stroke patients who were treated at RSI JS Surabaya from January 2019 to December 2021. Statistical analysis in this study used the chi-square correlation test. The results showed that the duration of hospitalization and bleeding volume had a significant correlation with the mortality in stroke patients (p-value<0.05) with OR (95% CI) are 0.243 (0.082-0.723) and 0.154 (0.048-0.500) respectively. Bleeding volume has a correlation with mortality in this study. However, this study has only fewer samples and it can’t be generalized.
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Ahammed, Z., Hassanuzzaman, M., Anawarul Kibria, M., Mahfuzur Rahman Babul, M., Azam, A., Khan, M., Absar, M., & Rahman, M. (2017). Volume of intracerebral hemorrhage: A powerful predictor of 30-day mortality. British Journal of Medical, 4(3). https://doi.org/10.1161/01.str.24.7.987
Alerhand, S., & Lay, C. (2017). Spontaneous Intracerebral Hemorrhage. In Emergency Medicine Clinics of North America. 45(4);825–845. https://doi.org/10.1016/j.emc.2017.07.002
Alexandru Radu, R., Oana Terecoasa, E., Tiu, C., Ghita, C., Irina Purcaru, L., & Marinescu, A. (2020). Clinical Characteristics and Outcomes of Patients with Intracerebral Hemorrhage – A Feasibility Study on Romanian Patients. Journal of Medicine and Life, 13(2), 125–131. https://doi.org/10.25122/jml-2020-0042
An, S. J., Kim, T. J., & Yoon, B.-W. (2017). Epidemiology, Risk Factors, and Clinical Features of Intracerebral Hemorrhage: An Update. Journal of Stroke, 19(1), 3–10. https://doi.org/10.5853/jos.2016.00864
Benjamin, E. J., Virani, S. S., Callaway, C. W., Chamberlain, A. M., & Chang, A. R. (2018). Heart Disease and Stroke Statistics-2018 Update: A Report From the American Heart Association. Circulation. 137(12):67–e492. https://doi.org/10.1161/CIR.0000000000000558
Broderick, J. P., Brott, T. G., Duldner, J. E., Tomsick, T., & Huster, G. (2021). Volume of Intracerebral Hemorrhage A Powerful and Easy-to-Use Predictor of 30-Day Mortality. http://ahajournals.org
de Oliveira Manoel, A. L., Goffi, A., Zampieri, F. G., Turkel-Parrella, D., Duggal, A., Marotta, T. R., Macdonald, R. L., & Abrahamson, S. (2016). The critical care management of spontaneous intracranial hemorrhage: A contemporary review. Critical Care, 20(1). https://doi.org/10.1186/s13054-016-1432-0
Duan, X., Wen, Z., Shen, H., Shen, M., & Chen, G. (2016). Intracerebral Hemorrhage, Oxidative Stress, and Antioxidant Therapy. In Oxidative Medicine and Cellular Longevity (Vol. 2016). Hindawi Publishing Corporation. https://doi.org/10.1155/2016/1203285
Faghih-Jouybari, M., Raof, M. T., Abdollahzade, S., Jamshidi, S., Padegane, T., Ehteshami, S., & Fateh, S. (2021). Mortality and morbidity in patients with spontaneous intracerebral hemorrhage: A single-center experience. Current Journal of Neurology, 20(1), 32–36.
https://doi.org/10.18502/cjn.v20i1.6377
Forman, R., Slota, K., Ahmad, F., Garg, R., John, S., Da Silva, I., & Koffman, L. (2020). Intracerebral Hemorrhage Outcomes in the Very Elderly. Journal of Stroke and Cerebrovascular Diseases, 29(5), 104695. https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.104695
Gaist, D., Wallander, M.-A., Mcfeat, G., & García-Rodríguez, L. A. (2013). Antonio González-Pérez, MS Mortality after hemorrhagic stroke Data from general practice (The Health Improvement Network). Neurology, 81, 559–565. https://doi.org/10.1212/wnl.0b013e31829e6eff
Hong, K.-S., Bang, O. Y., Kang, D.-W., Yu, K.-H., Bae, H.-J., Lee, J. S., Heo, J. H., Kwon, S. U., Oh, C. W., Lee, B.-C., Kim, J. S., & Yoon, B.-W. (2013). Stroke Statistics in Korea: Part I. Epidemiology and Risk Factors: A Report from the Korean Stroke Society and Clinical Research Center for Stroke. Journal of Stroke, 15(1), 2. https://doi.org/10.5853/jos.2013.15.1.2
Houben, R., Schreuder, F. H. B. M., Bekelaar, K. J., Claessens, D., van Oostenbrugge, R. J., Staals, J. (2018). Predicting Prognosis of Intracerebral Hemorrhage (ICH): Performance of ICH Score Is Not Improved by Adding Oral Anticoagulant Use. Front Neurol. doi: 10.3389/fneur.2018.00100. PMID: 29541054; PMCID: PMC5836590.
Janis, L. S., Sacco, R. L., Kasner, S. E., Broderick, J. P., Caplan, L. R., Connors, J. J., Culebras, A., ... & Vinters, H. V. (2013). An Updated Definition of Stroke for the 21st Century. Stroke, 44(7), 2064–2089. https://doi.org/10.1161/str.0b013e318296aeca
Jolink, W. M. T., Klijn, C. J. M., Brouwers, P. J. A. M., Kappelle, L. J., & Vaartjes, I. (2015). Time trends in incidence, case fatality, and mortality of intracerebral hemorrhage. Neurology, 85(15), 1318–1324. https://doi.org/10.1212/WNL.0000000000002015
Kang, Z., Appleton, J. P., Bath, P. M., & Sprigg, N. (2017). Management of acute intracerebral haemorrhage – an update. Clinical Medicine, 17(2), 166–172.
Kim, S. M., Hwang, S. W., Oh, E.-H., & Kang, J.-K. (2013). Determinants of the Length of Stay in Stroke Patients. Osong Public Health and Research Perspectives, 4(6), 329–341.
https://doi.org/10.1016/j.phrp.2013.10.008
Lioutas, V. A., Beiser, A. S., Aparicio, H. J., Himali, J. J., Selim, M. H., Romero, J. R., & Seshadri, S. (2020). Assessment of Incidence and Risk Factors of Intracerebral Hemorrhage among Participants in the Framingham Heart Study between 1948 and 2016. JAMA Neurology, 77(10), 1252–1260. https://doi.org/10.1001/jamaneurol.2020.1512
Magid-Bernstein, J., Girard, R., Polster, S., Srinath, A., Romanos, S., Awad, I. A., & Sansing, L. H. (2022). Cerebral hemorrhage: Pathophysiology, treatment, and future directions. Circulation Research, 130(8), 1204–1229. https://doi.org/10.1161/CIRCRESAHA.121.319949
McGurgan, I. J., Ziai, W. C., Werring, D. J., Al-Shahi Salman, R., & Parry-Jones, A. R. (2021). Acute intracerebral haemorrhage: Diagnosis and management. Practical Neurology, 21(2), 128–136.
https://doi.org/10.1136/practneurol-2020-002763
Morotti, A., & Goldstein, J. N. (2016). Diagnosis and Management of Acute Intracerebral Hemorrhage. In Emergency Medicine Clinics of North America. 34(4), pp. 883–899. https://doi.org/10.1016/j.emc.2016.06.010
Panchal, H. N., Shah, M. S., & Shah, D. S. (2015). Intracerebral Hemorrhage Score and Volume as an Independent Predictor of Mortality in Primary Intracerebral Hemorrhage Patients. Indian Journal of Surgery, 77, 302–304. https://doi.org/10.1007/s12262-012-0803-2
Parry-Jones, A. R., Moullaali, T. J., & Ziai, W. C. (2020). Treatment of intracerebral hemorrhage: From specific interventions to bundles of care. In International Journal of Stroke (Vol. 15, Issue 9, pp. 945–953). SAGE Publications Inc. https://doi.org/10.1177/1747493020964663
Patel, V. D., Garcia, R. M., Swor, D. E., Liotta, E. M., Maas, M. B., & Naidech, A. (2020). Natural History of Infratentorial Intracerebral Hemorrhages: Two Subgroups with Distinct Presentations and Outcomes. Journal of Stroke and Cerebrovascular Diseases, 29(8), 104920. https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.104920
Pinho, J., Costa, A. S., Araújo, J. M., Amorim, J. M., & Ferreira, C. (2019). Intracerebral hemorrhage outcome: A comprehensive update. Journal of the Neurological Sciences, 398, 54–66. https://doi.org/10.1016/j.jns.2019.01.013
Radu, R. A., Terecoasa, E. O., Tiu, C., Ghita, C., Purcaru, L. I., Marinescu, A. N., & Bajenaru, O. A. (2020). Clinical Characteristics and Outcomes of Patients with Intracerebral Hemorrhage – A Feasibility Study on Romanian Patients. Journal of Medicine and Life, 13(2), 125–131. https://doi.org/10.25122/jml-2020-0042
Rajashekar, D., & Liang, J. W. (2023). Intracerebral Hemorrhage Continuing Education Activity (1st ed.). StatPearls
Safatli, D., Günther, A., Schlattmann, P., Schwarz, F., Kalff, R., & Ewald, C. (2016). Predictors of 30-day mortality in patients with spontaneous primary intracerebral hemorrhage. Surgical Neurology International, 7(19), 510. https://doi.org/10.4103/2152-7806.187493
Stephen, A & Cappi, L. (2017). Spontaneous Intracerebral Hemorrhage. Emergency Medicine Clinics of North America. 35(4):825-845. https://doi.org/10.1016/j.emc.2017.07.002
Yudiarto F, Machfoed M., Darwin A., Ong A., Karyana M. & Siswanto. (2014). Indonesia stroke Registry (S12.003). Neurology, 82(10).
DOI: http://dx.doi.org/10.30742/jikw.v12i2.2880
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