Pengaruh Pemberian Sarang Telur Laba-Laba (Spider Silk Protein) Menemerus Bivittatus Secara Topikal Terhadap Penyembuhan Luka Insisi Pada Fase Inflamasi Tikus Putih Jantan (Rattus Norvegicus) Strain Wistar

Muhammad Yusak Alfaris, Mas Mansyur


The healing of wounds is a natural process of the human body but often medicine is used, for example the use of spider silk. The purpose of this research is to know the effect of the use of spider (Menemerus Bivittatus) silk protein used topically for the healing of incision wounds in the inflammatory phase. This research is a laboratory experiment. The subjects of this research are 18 wistar rats (Rattus Norvegicus strain) that are treated in two different ways. The first is control (K1) with the use of normal saline and the second is treatment (Pl) with the use of spider silk protein topically using wound dressing. The selection of samples is done randomly using the simple random sampling. The hypothesis testing uses the Chi Square testing with α = 0.05. The results of this research shows that the use of spider silk protein topically effects the process of incision wound healing (0,005) in the inflammatory phase (0,000) on Wistar rats.


incision wound; spider silk protein; inflammatory phase

Full Text:



Sherwood L. 2001. Human physiology: from cell to system, A Division of International Thomson Publishing Inc. pp 402-404.

Enoch S and Price P, 2004. Cellular, Molecular, and Biochemical Differences in the Pathophysiology of Healing Between Acute Wounds, Cronic Wounds, and Wound in the Aged. pp 32-33.

Sjamsuhidayat R and Jong D, 2011. Buku Ajar Ilmu Bedah. Edisi 3 , Penerbit Buku Kedokteran EGC, Jakarta. pp 395-399.

Gosain, A and DiPietro, LA, 2004. Aging and Wound Healing. World Journal of Surgery, 28(3), 321-326.

Perdanakusuma D, 2007, From Caring to Curing Pause Before You Use Gauze, Airlangga University School of Medicine, Surabaya.

Mustoe TA, O'Shaughnessy K, and Kloeters O, 2006. Chronic wound pathogenesis and current treatment strategies: a unifying hypothesis. J Plast Reconstr Surg.117:35–41.

Henderson EA, 2006. The potential effect of fibroblast senescence on wound healing and the chronic wound environment. J Wound Care.15:315–318.

Menke N, Ward K, Witten T, Bonchev D, Diegelman R, 2007, Impaired wound healing. Clin Dermatol. 25:19 25.

BPOM RI, 2010, Acuan Sediaan Herbal, Volume Lima, Badan Pengawasan Obat dan Makanan, Jakarta.

WHO.Traditional Medicine 2003. Availble from:

Tammelin A, Lindholm C, and Hambraeus A, 2002 Chronic ulcers and antibiotic treatment. J Wound Care. 7:435-437.

Howell JRS, Wilson MJ, Hill KE, Howard AJ, Price PE, Thomas DW, 2005. A review of the microbiology, antibiotic usage and resistance in chronic skin wounds. J Antimicrob Chemother; 55:143-9.

Isrofah, Sagiran dan Afandi M, Efektifitas Salep Ekstrak Daun Binahong (Anredera Cordifolia Ten Steenis) Terhadap Proses Penyembuhan Luka Bakar Derajat 2 Termal pada Tikus Putih (Rattus Novergicus). Muhammadiyah Journal of Nursing

Wirastuty RY, 2016, Uji efektifitas gel ekstrak kulit batang kayu jawa (Lannea Coromandelica) pada kelinci (Oryctolagus Cuniculuis) Sebagai obat penyembuh luka bakar, Journal ofPharmaceutical Science and Herbal Technology Vol.1 No.1

Kumar, 2005. Spider’s silk: Investigation of spinning process, web material and its properties. Biological Sciences and Bioengineering. IIT. Kanpur.

Bryant R, 2007. Acute and cronic wound. Current Management Concept Philadelphia: Mosby Elsevier. P 125.



  • There are currently no refbacks.

Copyright (c) 2017 Muhammad Yusak Alfaris, Mas Mansyur

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.



Jurnal Ilmiah Kedokteran Wijaya Kusuma 

ISSN: 1978-2071(print); 2580-5967 (online)
Published by the Institute for Research and Community Services (LPPM) of University of Wijaya Kusuma Surabaya.
Surabaya, Indonesia
Creative Commons License
All publications by Jurnal Ilmiah Kedokteran Wijaya Kusuma are licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
counter View My Stats