Peranan Stres Oksidatif pada Proses Penyembuhan Luka

Handy Arief, M Aris Widodo

Abstract


Wound healing is a complex dynamic process characterized by a series of events that occur in almost all type of tissue damage. In the early phase of the inflammatory response, neutrophils and macrophages enters into the injured tissue and the cells produce reactive oxygen species that can give a beneficial or detrimental effects. Oxidative stress is a condition occurs that shows imbalance between prooxidant or free radical and antioxidant that have a function to maintain the condition of the tissue damage that occurs. So Oxidative stress occurs when the production of Reactive Oxygen Species occurring is higher than the antioxidants existing as an intrinsic defense. Reactive Oxygen Species and Reactive Nitrogen Species are important components in the healing process of wounds and is necessary to be in the state of homeostasis to prevent oksidatif stress. The major components of ROS are superoxide (O2), hydroxyl radical (OH) and hydrogen peroxide (H2O2), which includes RNS are nitric oxide (NO), nitrous oxide (NO2), nitroxyl anion (HNO) and peroxynitrite (ONOO-) which could be form by the reaction between superoxide and nitric oxide. The existence of excessive O2 amount in the wound and the presence of excess NO can increase the incidence of oxidative stress that interfere with wound healing process. Oxidative stress plays a role in the inflammatory phase, proliferation and remodeling phase by increasing angiogenesis and affect other cells including endothelial cells in secreting NO. So the strategy in controlling oxidative stress is by increasing antioxidant level which is a scavenger to free radical excessive superoxide formation so preventing interference with the wound healing process.

 


Keywords


Oxidative Stress, ROS, RNS, Antioxidant, Wound Healing.

Full Text:

PDF

References


Luchi, Y., et al, 2010. Spontaneous skin damage and delayed wound healing in SOD1-deficient mice. Mol Cell Biochem. 341; 181-194.

Vermeij, W.P., Backendorf, C., 2010. Skin Cornification Proteins Provide Global Link between ROS Detoxification and Cell Migration during Wound Healing. PLoS ONE. 5(8); e11957; 1-7

Valko, M., Leibfritz, D., Moncol, J., Cronin, M.T.D., Mazur, M., Telser, J., 2007. Free radicals and antioxidants in normal physiological functions and human disease. The International Journal of Biochemistry & Cell Biology. 39 (1); 44-84

Soreja , A., Drews, M., Malinski, T., 2005. Role of nitric oxide, nitroxidative and oxidative stress in wound healing. Pharmacological reports. 57; 108-119

Chiu, J., Dawes, I.W., 2012. Redoxs control of cell proliferation. Trends in Cell Biology. 22 (11); 592-601

Schäfer, M., Werner, S., 2008. Oxidative stress in normal and impaired wound repair. Pharmacological Research. 58 (2); 165-171

Ardhie, A. M., 2011. Radikal Bebas dan peran Antioksidan dalam Mencegah Penuaan. Medicinus. 24 (1); 4-9

Burton, G. J., Jauniaux, E., 2011. Oxidative stress. Best Practice & Research Clinical Obstetrics and Gynaecology. 25; 287-298

Madamanchi, N.G., Vendrov, A., Runge, M.S., 2005. Oxidative Stress and Vascular Disease. Arterioscler Thromb Vasc Biol. 25; 29-38

Schremi, S., Szeimies, R. M., Prantl, L., Landthaler, M., Babilas, P., 2010. Oxygen in Acute and Chronic Wound Healing. The British Journal of Dermatology. 163 (2); 257-268

Vogiatzi, G., Tousoulis, D., Stefanadis, C., 2009. The Role of Oxidative Stress in Atherosclerosis. Hellenic J cardiol. 50; 402-409

Ushio-Fukai, M., Nakamura, Y., 2008. Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy. J Cancer Letters. 266; 37-52

Rahman, K., 2007. Studies on free radicals, antioxidants, and co-factors. Clinical Intervention in Aging. 2 (2); 219-236.




DOI: http://dx.doi.org/10.30742/jikw.v5i2.338

Refbacks

  • There are currently no refbacks.


Copyright (c) 2016 Handy Arief

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

 

garuda

Jurnal Ilmiah Kedokteran Wijaya Kusuma 

ISSN: 1978-2071(print); 2580-5967 (online)
 
Published by the Institute for Research and Community Services (LPPM) of University of Wijaya Kusuma Surabaya.
Surabaya, Indonesia
 
Creative Commons License
All publications by Jurnal Ilmiah Kedokteran Wijaya Kusuma are licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
 
web
counter View My Stats