Methicillin-Resistant Staphylococcus aureus Secondary Infection as a Comorbid in Crusted Scabies Patient

Anggun Putri Yuniaswan, Arista Putri Rakhmana Sari

Abstract


Introduction: Crusted scabies (CS) is characterized by uncontrolled proliferation of mites up to thousands. Complications include glomerulonephritis, rheumatic fever, and secondary infection which can cause bacteremia and sepsis. This case report describes a case of CS that was hospitalized with secondary complications of MRSA infection. Case Presentation: A 44-year-old woman complained of thick scales and itching all over her body for 6 months. Complaints begin with reddish bumps between the fingers, toes, body, genitals, and scalp, accompanied by itching, especially at night. The patient took self-purchased corticosteroids for this complaint for 6 months. Dermatology status all over the body showed erythematous papules plaques with greenish-yellow scales, blackish crusts, hyperkeratosis, and excoriation, also erythematous base erosions and blackish crusts in the right thoracic region. Ectoparasite scrapping examination showed large amounts of Sarcoptes scabiei, eggs, and scybala, so the patient was diagnosed with Crusted scabies. A wound culture and nasal swab showed MRSA. The patient died of septic shock on day 12 of treatment. Discussion: Crusted scabies is a highly contagious form of scabies, characterized by thickening of the skin layer and crusts. Long-term corticosteroid consumption in this case caused a compromised immune response so that the number of mites multiplied rapidly and increased the risk of MRSA infection. MRSA mortality rates range from 5-60%. Conclusion: Ignored cases of scabies can develop into crusted scabies which have a high risk of secondary infection, such as MRSA which can cause serious morbidity and even mortality.


Keywords


Crusted scabies, Methicillin-Resistant Staphylococcus aureus

Full Text:

PDF

References


Abdul H. Siddiqui, & Janak Koirala. (2023). Methicillin-resistant Staphylococcus aureus. In Treasure Island (FL): StatPearls Publishing. https://pubmed.ncbi.nlm.nih.gov/29489200/

Alexandris, D., Alevizopoulos, N., Nennes, P., Basagianni, E., Rousou, P., Kioupi, M., & Gerakini, F. (2024). Case report of crusted scabies, brief review of its pathophysiology and latest data. AME Case Reports, 8, 30–30. https://doi.org/10.21037/ACR-23-125

Arlian, L. G., & Morgan, M. S. (2017). A review of Sarcoptes scabiei: past, present and future. Parasites & Vectors, 10(1). https://doi.org/10.1186/S13071-017-2234-1

Asnawi, V., Maulida, M., Hidayati, A., Gunawan, H., Hindritiani, R., & Dwiyana, R. F. (2023). Combination of Crusted Scabies with Bullous Scabies: A Rare Case. International Medical Case Reports Journal, 16, 153–158. https://doi.org/10.2147/IMCRJ.S396234

Bhat, S. A., Mounsey, K. E., Liu, X., & Walton, S. F. (2017). Host immune responses to the itch mite, Sarcoptes scabiei, in humans. Parasites & Vectors 2017 10:1, 10(1), 1–12. https://doi.org/10.1186/S13071-017-2320-4

Chandler, D. J., & Fuller, L. C. (2019). A Review of Scabies: An Infestation More than Skin Deep. Dermatology (Basel, Switzerland), 235(2), 79–80. https://doi.org/10.1159/000495290

Davis, J. S., McGloughlin, S., Tong, S. Y. C., Walton, S. F., & Currie, B. J. (2013). A novel clinical grading scale to guide the management of crusted scabies. PLoS Neglected Tropical Diseases, 7(9). https://doi.org/10.1371/JOURNAL.PNTD.0002387

Engelman, D., Yoshizumi, J., Hay, R. J., Osti, M., Micali, G., Norton, S., Walton, S., Boralevi, F., Bernigaud, C., Bowen, A. C., Chang, A. Y., Chosidow, O., Estrada-Chavez, G., Feldmeier, H., Ishii, N., Lacarrubba, F., Mahé, A., Maurer, T., Mahdi, M. M. A., … Fuller, L. C. (2020). The 2020 International Alliance for the Control of Scabies Consensus Criteria for the Diagnosis of Scabies. British Journal of Dermatology, 183(5), 808–820. https://doi.org/10.1111/BJD.18943

Khan, T. M., Kok, Y. L., Bukhsh, A., Lee, L. H., Chan, K. G., & Goh, B. H. (2018). Incidence of methicillin resistant Staphylococcus aureus (MRSA) in burn intensive care unit: a systematic review. Germs, 8(3), 113–125. https://doi.org/10.18683/GERMS.2018.1138

Lause, M., Libson, K., Korman, A. M., Colburn, N., Day, S., Greer, M., Hardgrow, M., Malcolm, K., Mcginnis, M., Seely, E., Smyer, J., & Trinidad, J. (2023). Crusted scabies at a tertiary care center: Case series and cautionary tale. JAAD Case Reports, 41, 17. https://doi.org/10.1016/J.JDCR.2023.08.030

Leung, A. K. C., Leong, K. F., Lam, J. M., & Li, A. M. (2019). Pruritic Crusted Scabies in an Immunocompetent Infant. Case Reports in Pediatrics, 2019(1), 9542857. https://doi.org/10.1155/2019/9542857

Lin, S., Farber, J., & Lado, L. (2009). A case report of crusted scabies with methicillin-resistant Staphylococcus aureus bacteremia. Journal of the American Geriatrics Society, 57(9), 1713–1714. https://doi.org/10.1111/J.1532-5415.2009.02412.X

Lydiawati, E., Agusni, I., Murtiastutik, D., Ervianti, E., Sawitri, Indranarum, T., Widyantari, S., & Mappamasing, H. (2019). Crusted scabies in systemic lupus erythematosus: More than a mite contagious case. Dermatology Reports, 11(s1), 163–165. https://doi.org/10.4081/dr.2019.8085

Manyindo, N., Pamireddy, P., McDonald, M., Vijayan, J., Adenuga, B., & Adams, R. (2022). Severe methicillin-resistant staphylococcus aureus septicemia in a case of misdiagnosed crusted (Norwegian) scabies. Clinical Geriatrics, 19(8), 43–47. https://www.researchgate.net/publication/289162301_Severe_methicillin-resistant_staphylococcus_aureus_septicemia_in_a_case_of_misdiagnosed_crusted_Norwegian_scabies

Meraz Soto, J. M., Alvarado Motte, R. A., Ramírez Carrillo, P., Meraz Soto, A. A., Bayón Villaseñor, V., & Cheirif Wolosky, O. (2023). Crusted Hyperkeratotic Scabies: A Case Report. Cureus, 15(2). https://doi.org/10.7759/CUREUS.34520

Murray RL, & Crane JS. (2024). Scabies - StatPearls - NCBI Bookshelf. Treasure Island (FL): StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK544306/

Niode, N. J., Adji, A., Gazpers, S., Kandou, R. T., Pandaleke, H., Trisnowati, D. M., Tumbelaka, C., Donata, E., Djaafara, F. N., Kusuma, H. I., Rabaan, A. A., Garout, M., Almuthree, S. A., Alhani, H. M., Aljeldah, M., Albayat, H., Alsaeed, M., Alfouzan, W. A., Nainu, F., … Tallei, T. E. (2022). Crusted Scabies, a Neglected Tropical Disease: Case Series and Literature Review. Infectious Disease Reports, 14(3), 479–491. https://doi.org/10.3390/IDR14030051

Rahdar, M., & Maraghi, S. (2019). Norwegian Scabies in Two Immune-Compromised Patients: A Case Report. Iranian Journal of Public Health, 48(6), 1169–1173. https://doi.org/10.18502/IJPH.V48I6.2933

Rahmawati, N. A., Chomariyati, A., & Mudjanarko, S. W. (2022). A fatal case of Norwegian scabies in a patient with diabetes mellitus. Bali Medical Journal, 11(2), 870–874. https://doi.org/10.15562/BMJ.V11I2.3500

Rosumeck, S., Nast, A., & Dressler, C. (2018). Ivermectin and permethrin for treating scabies. The Cochrane Database of Systematic Reviews, 4(4). https://doi.org/10.1002/14651858.CD012994

Ständer, S., & Ständer, S. (2021). Itch in Scabies—What Do We Know? Frontiers in Medicine, 8, 628392. https://doi.org/10.3389/FMED.2021.628392

Sunderkötter, C., Wohlrab, J., & Hamm, H. (2021). Scabies: Epidemiology, Diagnosis, and Treatment. Deutsches Arzteblatt International, 118(41), 695–704. https://doi.org/10.3238/ARZTEBL.M2021.0296

Wijaya, H., Kollins, F., Lubis, I. ND., Pasaribu, A. P., Evalina, R., Nababan, K. A., & Paramita, D. A. (2024). Norwegian scabies in human immunodeficiency virus and tuberculosis-infected child: A case report. Narra J, 4(1), e661. https://doi.org/10.52225/NARRA.V4I1.661

World Health Organization. (2020). Scabies. https://www.who.int/news-room/fact-sheets/detail/scabies

Zhang, L. Y., Yu, X., Zou, J. J., Hu, Y. H., Jie, L., Wu, Y. W., & Fang, M. P. (2022). Norwegian Scabies Mimicking Seborrheic Scalp Dermatitis in a Patient with Chronic Hepatitis C. International Journal of Dermatology and Venereology, 3(1), 52–55. https://doi.org/10.1097/JD9.0000000000000059




DOI: http://dx.doi.org/10.30742/jikw.v13i2.3630

Refbacks

  • There are currently no refbacks.


Copyright (c) 2024 Anggun Putri Yuniaswan, Arista Putri Rakhmana Sari

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Jurnal Ilmiah Kedokteran Wijaya Kusuma is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License