ASYMMETRIC DIMETHYLARGININE
DOI:
https://doi.org/10.30742/jikw.v2i1.77Keywords:
Asymmetric dimethylarginine (ADMA), nitric oxide, endothelial and cardiovascular hence, end-stage renal diseaseAbstract
Asymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human cells. It is closely related to L-arginine, a conditionally-essential amino acid. ADMA interferes with L-arginine in the production of nitric oxide, a key chemical to endothelial and hence cardiovascular health. ADMA
concentration is elevated in patients with end-stage renal disease (ESRD), in part because it is excretedvia the kidneys.
References
Abbasi F, Asagmi T, Cooke JP, Lamendola C, McLaughlin T, Reaven
GM 2001 Plasma concentrations of asymmetric dimethylarginine are increased in patients with type 2 diabetes mellitus.
Am J Cardiol 88:1201–1203 Baylis C, Mitruka B, Deng A: Chronic
blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damage.J Clin Invest 90:278 - 281, 1992
Boger RH, Bode-Boger SM, Brandes RP, Phivthong-ngam L, Bohme M, Nafe Boger RH, Sydow K, Borlak J, Thum T, Lenzen H, Schubert B, Tsikas D, Bode-
Boger SM (2000). "LDL cholesterol upregulates synthesis of asymmetrical
dimethylarginine in human endothelial cells: involvement of S-
adenosylmethionine-dependent methyltransferases". Circ Res 87 (2): 99-
Cooke, J.P. and D.W. Losordo, Nitric oxide and angiogenesis. Circulation, 2002. 105(18): p. 2133-5.
Ceremuzynski L, Chamiec T, Herbaczynska-Cedro K (1997). "Effect of supplemental oral L-arginine on exercise capacity in patients with stable
angina pectoris". Am J Cardiol 80 (3): 331-3.
Fard, A., et al., Acute elevations of plasma asymmetric dimethylarginine and impaired endothelial function in response to a high-fat meal in patients with type 2 diabetes [In Process Citation]. Arterioscler
Thromb Vasc Biol, 2000. 20(9): p. 2039-44.
Janatuinen T, Laakso J, Laaksonen R,Vesalainen R, Nuutila P, Lehtimaki T,
Raitakari OT, Knuuti J (2003). "Plasma asymmetric dimethylarginine modifies the effect of pravastatin on myocardial blood
flow in young adults". Vasc Med 8 (3):185-9.
Kielstein JT, Boger RH, Bode-Boger SM, Schaffer J, Barbey M, Koch KM,
Frolich JC 1999 Asymmetric dimethylarginine plasma concentrationsdiffer in patients with end-stage renal disease: relationship to treatment method and atherosclerotic disease. J Am Soc Nephrol 10:594–600
R, et al.: Dietary L-arginine reduces the progression of atherosclerosis in cholesterol-fed rabbits: comparison with lovastatin. Circulation 1997, 96(4):1282-1290
Boger, R.H. and S.M. Bode-Boger, Asymmetric dimethylarginine, derangements of the endothelial nitric oxide synthase pathway, and
cardiovascular diseases. Semin Thromb Hemost, 2000. 26(5): p. 539-45.
London GM, Drüeke TB: Atherosclerosis and arteriosclerosis in chronic renal failure. Kidney Int51 : 1678- 1695,1997
Lindner A, Charra B, Sherrard DJ, Scribner BH: Accelerated atherosclerosis in prolonged maintenance hemodialysis. N Engl J Med 290: 697-701,1974
Moncada S, Higgs A: The L-arginine- nitric oxide pathway. N Engl J Med
:2002 -2012, 1993
Najbauer, J., et al., Peptides with sequences similar to glycine, arginine-rich motifs in proteins interacting with RNA
are efficiently recognized by methyltransferase(s) modifying arginine in
numerous proteins. J Biol Chem, 1993. 268(14): p. 10501-9.
Rees DD, Palmer RM, Hodson HF, Moncada S: A specific inhibitor of nitric
xide formation from L-arginine attenuates endothelium-dependent relaxation. Br J Pharmacol 96:418 -424, 1989
Rector TS, Bank AJ, Mullen KA, Tschumperlin LK, Sih R, Pillai K, Kubo
SH (1996). "Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failure". Circulation 93 (12): 2135-41
Stuhlinger MC, Abbasi F, Chu JW, Lamendola C, McLaughlin TL, Cooke
JP, Reaven GM, Tsao PS 2002 Relationship between insulin resistance and an endogenous nitric oxide synthase inhibitor. JAMA 287:1420–1426
Stuhlinger, M., et al., Endothelial dysfunction induced by hyperhomocyst(e)inemia - Role of ADMA. 2003: Stanford.
Surdacki, A., et al., Reduced urinary excretion of nitric oxide metabolites and increased plasma levels of asymmetric dimethylarginine in men with essential
hypertension. J Cardiovasc Pharmacol, 1999. 33(4): p. 652-8. Sydow, K., et al., ADMA and oxidative stress are responsible for endothelial dysfunction in hyperhomocyst(e)inemia:effects of L-arginine and B vitamins.
Cardiovasc Res, 2003. 57(1): p. 244-52. Teerlink, T., et al., Estrogen replacement therapy lowers plasma levels of asymmetric dimethylarginine in healthy postmenopausal women. Clin Sci (Lond),
Tsao, P.S., et al., Nitric oxide regulates monocyte chemotactic protein-1.
Circulation, 1997. 96(3): p. 934-40.
Wolf A, Zalpour C, Theilmeier G, Wang BY, Ma A, Anderson B, et al.:
Dietary L-arginine supplementation normalizes platelet aggregation in
hypercholesterolemic humans. J Am Coll Cardiol 1997, 29(3):479-485
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