Infeksi COVID-19 pada kehamilan dengan insulin dependent diabetes mellitus (IDDM)

Arif Rahman Nurdianto, Rizal Fauzi Nurdianto, Dyah Ayu Febiyanti


Research on pregnancies with insulin dependent diabetes mellitus (IDDM) infected with COVID-19 is very limited. In pregnant conditions, there is a shift from Th1 to Th2 and physiological changes that make it very susceptible to being infected by COVID-19 in pregnancy, in addition to complaints that are similar between changes due to pregnancy and symptoms of COVID-19. The aim of this study was to Explain the effect of COVID-19 infection in pregnant women with IDDM. This study was conducted using a descriptive method of clinical and laboratory examination results of one pregnant patient aged 26 years with IDDM and infected with COVID-19 at the Trosobo Health Center. The variables in this study were the results of clinical and laboratory examinations of patients during treatment. All data were then analyzed descriptively according to the latest journal literature. Result of this study showed that Pregnant women with IDDM and infected with COVID-19 might have disorders of the lung organs in the form of pneumonia on X-rays, disturbances in laboratory test and minor clinical disorders. In addition, it is important to note that the presence of heart problems as indicated by disturbances in the rhythm of the post partum ECG. COVID-19 infection in pregnant women with IDDM can show mild or severe symptoms such as heart problems and further research is needed on the effect of this infection with a larger sample.


COVID-19; Insulin dependent diabetes mellitus; kehamilan; Th1; Th2

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Alfaraj SH, Al-Tawfiq JA, Memish ZA, 2019. Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection during Pregnancy: Report of Two Cases & Review of the Literature. J Microbiol Immunobiol Infect. 52(3): 501–503.

Angeletti S, Benvenuto D, Bianchi M, Giovanetti, M, Pascarella S et al, 2020. COVID-2019: the Role of the nsp2 and nsp3 in its Pathogenesis. J. Med. Virol. 2020, 1–5.

Ashokka B, Loh MH, Tan CH, Su LL, Young BE, Lye DC et al 2020. Care of the Pregnant Woman with COVID-19 in Labor and Delivery: Anesthesia, Emergency Cesarean Delivery, Differential Diagnosis in the Acutely Ill Parturient, Care of the Newborn, and Protection of the Healthcare

Personnel. Am J Obstet Gynecol. 223(1): 66-74

Breslin N, Baptiste C, Gyamfi-Bannerman C, Miller R, Martinez R et al, 2020. Coronavirus Disease 2019 Infection among Asymptomatic and Symptomatic Pregnant Women: Two Weeks of Confirmed Presentations to an Affiliated Pair of New York City Hospitals. American Journal of Obstetrics & Gynecology MFM. 2(2): 100-118

Chen L, Li Q, Zheng D, Jiang H, Wei Y et al, 2020. Clinical Characteristics of Pregnant Women with Covid-19 in Wuhan, China. Nengl j med. 382(25): 1-3.

Chen H, Guo J, Wang C, Luo F, Yu X et al, 2020. Clinical Characteristics and Intrauterine Vertical Transmission Potential of COVID-19 Infection in Nine Pregnant Women: a Retrospective Review of Medical Records. The Lancet. 395(10226): 809–815.

Coutard B, Valle C, de Lamballerie X, Canard B, Seidah N et al, 2020. The Spike Glycoprotein of The New Coronavirus 2019-Ncov Contains a Furin-Like Cleavage Site Absent in Cov of the Same Clade. Antivir Res. 176, 104742.

Dashraath P, Wong JLJ, Lim MXK, Lim LM, Li S, Biswas A et al, 2020. Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy. Am J Obstet Gynecol. 222(6): 521-531.

Dinas Kesehatan Kabupaten Sidoarjo. 2020. Laporan Kasus Kehamilan Dengan COVID-19 Agustus 2020.

Dong L, Tian J, He S, Zhu C, Wang J et al, 2020. Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn. JAMA. 323(18): 1846-1848.

Jawa Pos. 2020.RS di Sidoarjo Wajib Terima Bumil Positif. Jawa Pos; 18 Juli 2020. Diambil dari

Liang H and Acharya G, 2020. Novel Corona Virus Disease (COVID‐19) in Pregnancy: What Clinical Recommendations to Follow?. Acta Obstet Gynecol Scand. 99 (4): 439-442.

Jiao J, 2020. Under the Epidemic Situation Of COVID-19, Should Special Attention to Pregnant Women be Given?. J Med Virol. 92: 1371-1372.

Li G and Clercq ED, 2020. Therapeutic Options for the 2019 Novel Coronavirus (2019-nCoV). Nat Rev Drug Discov. 19, 1449–14150.

Liu D, Li L, Wu X, Zheng D, Wang J et al, 2020. Pregnancy and Perinatal Outcomes of Women With Coronavirus Disease (COVID-19) Pneumonia: A Preliminary Analysis. American Journal of Roentgenology. 215(1): 127-132.

Liu DX, Fung TS, Chong KK-L, Shukla A, Hilgenfeld R, 2014. Accessory Proteins of SARS-CoV and Other Coronaviruses. Antivir Res. 109: 97–109.

Liu H, Wang LL, Zhao SJ, Kwak-Kim J, Mor G et al. 2020. Why are Pregnant Women Susceptible to COVID-19? An Immunological Viewpoint. J Reprod Immunol. 2020. 139: 103122.

Liu YT, Chen HW, Lii CK, Jhuang JH, Huang CS et al, 2020a. A Diterpenoid, 14-Deoxy-11, 12-Didehydroandrographolide, in Andrographis Paniculata Reduces Steatohepatitis and Liver Injury in Mice Fed a High-Fat and Highcholesterol Diet. Nutrients. 12(2): 523.

Liu Z, Xiao X, Wei X, Li J, Yang J et al, 2020b. Composition and Divergence of Coronavirus Spike Proteins and Host ACE2 Receptors Predict Potential Intermediate Hosts of SARS-Cov-2. J Med Virol. 92(6): 595-601.

Lokken EK, Walker CL, Delaney S, Kachikis A, kretzer NM et al, 2020. Clinical Characteristics of 46 Pregnant Women with a Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Washington State. Am J

Obstet Gynecol. 2020: 1.e1-1.e14

LoMauro A and Aliverti A, 2015. Respiratory Physiology of Pregnancy: Physiology Masterclass. Breathe (Sheffield, England). 11(4): 297–301.

Martinellia I, Ferrazzib E, Ciavarella A, Errab R, Iurlarob E et al, 2020. Pulmonary Embolism in a Young Pregnant Woman with COVID-19. Thromb Res. 191: 36-37.

Mimouni F, Lakshminrusimha S, Pearlman SA, Raju T et al, 2020. Perinatal aspects on the covid-19 Pandemic: A Practical Resource for Perinatal–neonatal Specialists. Journal of Perinatology. 40(5): 820–826.

Mullins E, Evans D, Viner RM, O'Brien P, Morris E, 2020. Coronavirus in Pregnancy and Delivery: Rapid Review. Ultrasound in Obstetrics & Gynecology. 55: 586-592.

Negri EM, Piloto BM, Morinaga LK, Jardim CVP, Lamy SAE, et al 2020. Heparin Therapy Improving Hypoxia in COVID-19 Patients - a Case Series. medRxiv.

Nieto-Torres JL, Verdiá-Báguena C,Jimenez-Guardeño JM, Regla-Nava JA, Castaño-Rodriguez C et al, 2015. Severe Acute Respiratory Syndrome Coronavirus E Protein Transports Calcium Ions and Activates the NLRP3 Inflammasome. Virology, 485, 330–339.

Nurdianto AR, Aryati S, Suryokusumo MG, 2019a. Downregulates of ICAM1 expression in Myometrium from Pregnant Rattus norvegicus Infected with Tachyzoite of Toxoplasma gondii with Hyperbaric Oxygen Therapy. Hang tuah medical journal. 17: 77–83.

Nurdianto AR, Aryati, Suryokusumo MG, Mufasirin, 2019b. Effect of Hyperbaric Oxygen Therapy to IFN Gamma and TNF Alpha Expression In Pregnant Rattus novergicus Infected with Tachyzoite Of Toxoplasma gondii. Bali Medical Journal, 8(1): 94–100.

Nurdianto AR, Aryati, Suryokusumo MG, Mufasirin, Suwanti LT et al, 2020a. Effect of Hyperbaric Oxygen Therapy on ICAM-1 Expression in Artery Spiralis of Pregnant Rattus Norvegicus Infected by Tachyzoite From Toxoplasma gondii. EurAsian Journal of BioSciences Eurasia J Biosci. 14(1): 1757-1762.

Nurdianto AR, Aryati, Suryokusumo MG, Mufasirin, Suwanti LT, Sunarjo, Sardjono TW, Dachlan EG, 2020b. Effects of Hyperbaric Oxygen Therapy on IL-17, Fetal Body Weight and Total Fetus in Pregnant Rattus norvegicus Infected with Tachyzoite Toxoplasma gondii. Systematic Reviews in Pharmacy. 11(3): 628–634.

Qiao J, 2020. What are the Risks of COVID-19 Infection in Pregnant Women?. The Lancet. 395(10226): 760–762.

Rohmah MK and Nurdianto AR, 2020. Perspective of Molecular Immune Response of SARS-COV-2 Infection. Jurnal Teknologi Laboratorium. 9(1): 58–66.

Royal College of Obstetricians & Gynaecologists. Coronavirus (COVID-19) infection and pregnancy Version 7. 9 April 2020.

Salehi S, Abedi A, Balakrishnan S, Gholamrezanezhad A, 2020. Coronavirus Disease 2019 (COVID-19): A Systematic Review of Imaging Findings in 919 Patients. American Journal of Roentgenology: 1–7.

Siu KL, Yuen KS, Castaño-Rodriguez C, Ye ZW, Yeung ML et al, 2019. Severe Acute Respiratory Syndrome Coronavirus ORF3a Protein Activates the NLRP3 Inflammasome by Promoting TRAF3-dependent Ubiquitination of ASC. FASEB J. 33: 8865–8877.

Shi C-S, Nabar NR, Huang N-N, Kehrl JH, 2019. SARS-Coronavirus Open Reading Frame-8b Triggers Intracellular Stress Pathways and Activates NLRP3 Inflammasomes. Cell. Death. Discov. 5, 1–12.

Wu A, Peng Y, Huang B, Ding X, Wan X et al, 2020a. Genome Composition and Divergence of the Novel Coronavirus (2019-Ncov) Originating In China. Cell Host Microbe. 27, 325–328.

Wu C, Liu Y, Yang Y, Zhang P, Zhong W et al, 2020b. Analysis of Therapeutic Targets for SARS-Cov-2 and Discovery of Potential Drugs by Computational Methods. Acta Pharm Sin B. 10(5): 766-788.

Xu J, Zhao S, Teng T, Abdalla AE, Zhu W et al, 2020a. Systematic Comparison of Two Animal-To-Human Transmitted Human Coronaviruses: SARS-Cov-2 and SARS-Cov. Viruses. 12, 244.

Xu X, Yu C, Qu J, Zhang L, Jiang S et al, 2020b. Imaging and Clinical Features of Patients with 2019 Novel Coronavirus Sarscov-2. Eur J Nucl Med and Mol Imaging, 1–6.

Zeng Hui, Xu C, Fan J, Tang Y, Deng Q et al, 2020. Antibodies in Infants Born to Mothers With COVID-19 Pneumonia. JAMA. I323(18): 1848-1849.



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